Opinion – Lifelong Persistence of Toxoplasma Cysts: A Questionable Dogma?

December 19, 2016 at 8:06 am

Trends in Parasitology December 08, 2016

Solène Rougier, Jose G. Montoya, François Peyron

It is believed that infection by Toxoplasma gondii triggers a lifelong protective immunity due to the persistence of parasitic cysts which induce immunoprotection against reinfection.

A review of the scientific literature since the 1950s did not yield any definitive data regarding the duration of cysts in the host or the presence of lifelong protective immunity, which led us to question this dogma.

We put forward the hypothesis that sustained immunity to T. gondii requires repeated antigenic stimulations.

The decline of seroprevalence recently observed in many countries might contribute to explain the loss of immunity.

We address the potential consequences of this phenomenon, should it persist and worsen…

FULL TEXT

http://www.cell.com/trends/parasitology/fulltext/S1471-4922(16)30190-8

PDF

http://www.cell.com/trends/parasitology/pdf/S1471-4922(16)30190-8.pdf

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Entry filed under: Antiparasitarios, Biología Molecular, Epidemiología, Infecciones en embarzadas, Infecciones parasitarias, Infecciones y Alimentos, Metodos diagnosticos, REPORTS, REVIEWS, Update, Zoonosis.

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