Editor’s Choice: Effectiveness of Prenatal Tetanus, Diphtheria, and Acellular Pertussis Vaccination on Pertussis Severity in Infants

December 24, 2016 at 1:57 pm

Clinical Infectious Diseases January 1, 2017 V.64 N.1 P.9-14

Kathleen Winter, James D. Cherry, and Kathleen Harriman

1California Department of Public Health, Immunization Branch, Richmond

2Department of Epidemiology, University of Kentucky, Lexington

Background

All US women are recommended to receive a tetanus, diphtheria, and acellular pertussis (Tdap) vaccine at 27–36 weeks gestation during each pregnancy to reduce the risk of pertussis to their infants. The impact of this strategy on severity of disease among infected infants has not been evaluated.

Methods

We use a retrospective cohort study design evaluating whether pertussis-infected infants born in 2011–2015 whose mothers received Tdap vaccine during pregnancy had less severe pertussis, resulting in a lower risk of hospitalization or intensive care unit admission compared with infants born to unvaccinated mothers.

Results

Infected infants of vaccinated mothers were significantly less likely to be hospitalized and had significantly shorter hospital stays compared with infants born to unvaccinated mothers, after adjustment for chronological and gestational age and receipt of diphtheria and tetanus toxoids and acellular pertussis vaccine. Unadjusted and adjusted vaccine effectiveness for preventing hospitalization among infants with pertussis was 72% (95% confidence interval [CI], 49%–85%) and 58% (95% CI 15%–80%), respectively. No infants born to vaccinated mothers required intubation or died of pertussis.

Conclusions

Infants with pertussis whose mothers received Tdap during pregnancy had a significantly lower risk of hospitalization and intensive care unit admission and shorter hospital stays. Prenatal Tdap vaccination is a critical strategy for reducing the morbidity and mortality from pertussis.

PDF

https://cid.oxfordjournals.org/content/64/1/9.full.pdf+html

Entry filed under: Bacterias, Biología Molecular, Epidemiología, FIEBRE en el POST-VIAJE, Infecciones en embarzadas, Inmunizaciones, Medicina del viajero, Update. Tags: .

Editor’s Choice: Effectiveness of Prenatal Versus Postpartum Tetanus, Diphtheria, and Acellular Pertussis Vaccination in Preventing Infant Pertussis Editor’s Choice: Coinfection With Zika and Dengue-2 Viruses in a Traveler Returning From Haiti, 2016: Clinical Presentation and Genetic Analysis


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