Report of mecC-carrying MRSA in domestic swine

December 28, 2016 at 8:09 am

Journal of Antimicrobial & Chemotherapy January 1, 2017 V.72 N.1 P.60-63

Ø. Angen, M. Stegger, J. Larsen, B. Lilje, H. Kaya, K. S. Pedersen, A. Jakobsen, A. Petersen, and A. R. Larsen

1Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark

2Ø-Vet, Køberupvej 33, 4700 Næstved, Denmark

Objectives

We unexpectedly identified MRSA isolates carrying mecC (mecC-MRSA) from a Danish swine farm located in eastern Zealand. The objective of the present study was to investigate the origin of these isolates and their genetic relatedness to other mecC-MRSA isolates from Zealand.

Methods

WGS was used to infer the phylogenetic relationship between 19 identified mecC-MRSA isolates from the swine farm and 34 additional epidemiologically unrelated human isolates from the same geographical region of Denmark. Variations in the accessory genome were investigated by bioinformatics tools, and antibiotic susceptibility profiles were assessed by MIC determination.

Results

mecC-MRSA was isolated from a domestic swine farm, but not from cattle reared at the same farm. Phylogenetic analysis revealed that all mecC-MRSA isolates from both farm animals and workers formed a separate cluster, whereas human isolates from the same municipality belonged to a closely related cluster. Analysis of the accessory genome supported this relationship.

Conclusions

To the best of our knowledge, this is the first report of mecC-MRSA isolated from domestic swine. The investigation strongly indicates that transmission of mecC-MRSA has taken place on the swine farm between the farmers and swine. The close clustering of farm isolates and isolates from the same municipality suggests a local transmission of mecC-MRSA.

PDF

http://jac.oxfordjournals.org/content/72/1/60.full.pdf+html

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Biología Molecular, Epidemiología, Metodos diagnosticos, Resistencia bacteriana, REVIEWS, Sepsis, Update, Zoonosis.

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