Linezolid: a promising option in the treatment of Gram-positives

January 24, 2017 at 8:05 am

Journal of Antimicrobial Chemotherapy February 2017 V.72 N.2 P.354-364

EDITOR’S CHOICE

Abed Zahedi Bialvaei; Mohammad Rahbar; Mehdi Yousefi; Mohammad Asgharzadeh; Hossein Samadi Kafil

Linezolid, an oxazolidinone antimicrobial agent that acts by inhibiting protein synthesis in a unique fashion, is used in the treatment of community-acquired pneumonia, skin and soft-tissue infections and other infections caused by Gram-positive bacteria including VRE and methicillin-resistant staphylococci. Currently, linezolid resistance among these pathogens remains low, commonly <1.0%, although the prevalence of antibiotic resistance is increasing in many countries. Therefore, the development of resistance by clinical isolates should prompt increased attention of clinical laboratories to routinely perform linezolid susceptibility testing for this important agent and should be taken into account when considering its therapeutic use. Considering the importance of linezolid in the treatment of infections caused by Gram-positive bacteria, this review was undertaken to optimize the clinical use of this antibiotic.

FULL TEXT

https://academic.oup.com/jac/article/72/2/354/2629138/Linezolid-a-promising-option-in-the-treatment-of

PDF

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Infecciones en piel y tej blandos, Infecciones respiratorias, Metodos diagnosticos, REPORTS, Resistencia bacteriana, REVIEWS, Sepsis, Update.

Gordonia species: emerging pathogens in pediatric patients that are identified by 16S ribosomal RNA gene sequencing. Analysis of linezolid and tigecycline as candidates for local prophylaxis via antibiotic-loaded bone cement


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