Inhibition of Plasmodium Liver Infection by Ivermectin

January 25, 2017 at 2:29 pm

Antimicrobial Agents & Chemotherapy February 2017 V.61 N.2 e02005-16

António M. Mendes, Inês S. Albuquerque, Marta Machado, Joana Pissarra, Patrícia Meireles, and Miguel Prudêncio

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal

Avermectins are powerful endectocides with an established potential to reduce the incidence of vector-borne diseases. Here, we show that several avermectins inhibit the hepatic stage of Plasmodium infection in vitro. Notably, ivermectin potently inhibits liver infection in vivo by impairing parasite development inside hepatocytes. This impairment has a clear impact on the ensuing blood stage parasitemia, reducing disease severity and enhancing host survival. Ivermectin has been proposed as a tool to control malaria transmission because of its effects on the mosquito vector. Our study extends the effect of ivermectin to the early stages of mammalian host infection and supports the inclusion of this multipurpose drug in malaria control strategies.

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http://aac.asm.org/content/61/2/e02005-16.full.pdf+html

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Entry filed under: Antiparasitarios, Infecciones intraabdominales, Infecciones parasitarias, Medicina del viajero, Metodos diagnosticos, REPORTS, Sepsis, Update.

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