Impact of Ultraviolet Germicidal Irradiation for No-Touch Terminal Room Disinfection on Clostridium difficile Infection Incidence Among Hematology-Oncology Patients.

February 2, 2017 at 9:05 pm

Infect Control Hosp Epidemiol. January 2017 V.38 N.1 P.39-44.

Pegues DA1, Han J1, Gilmar C2, McDonnell B3, Gaynes S4.

Author information

11Division of Infectious Diseases,Perelman School of Medicine at the University of Pennsylvania,Philadelphia,Pennsylvania.

22Department of Healthcare Epidemiology,Infection Prevention and Control,Hospital of the University of Pennsylvania,Philadelphia,Pennsylvania.

33Operations Improvement,Hospital of the University of Pennsylvania,Philadelphia,Pennsylvania.

44Department of Environmental Services,Hospital of the University of Pennsylvania,Philadelphia,Pennsylvania.

OBJECTIVE To evaluate the impact of no-touch terminal room no-touch disinfection using ultraviolet wavelength C germicidal irradiation (UVGI) on C. difficile infection (CDI) rates on inpatient units with persistently high rates of CDI despite infection control measures.

DESIGN Interrupted time-series analysis with a comparison arm.

SETTING 3 adult hematology-oncology units in a large, tertiary-care hospital.

METHODS We conducted a 12-month prospective valuation of UVGI. Rooms of patients with CDI or on contact precautions were targeted for UVGI upon discharge using an electronic patient flow system. Incidence rates of healthcare-onset CDI were compared for the baseline period (January 2013-December 2013) and intervention period (February 2014-January 2015) on study units and non-study units using a mixed-effects Poisson regression model with random effects for unit and time in months.

RESULTS During a 52-week intervention period, UVGI was deployed for 542 of 2,569 of all patient discharges (21.1%) on the 3 study units. The CDI rate declined 25% on study units and increased 16% on non-study units during the intervention compared to the baseline period. We detected a significant association between UVGI and decrease in CDI incidence (incidence rate ratio [IRR], 0.49; 95% confidence interval [CI], 0.26-0.94; P=.03) on the study units but not on the non-study units. The impact of UVGI use on average room-cleaning time and turnaround time was negligible compared to the baseline period.

CONCLUSIONS Targeted deployment of UVGI to rooms of high-risk patients at discharge resulted in a substantial reduction of CDI incidence without adversely impacting room turnaround.

Terminal room disinfection with germicidal ultraviolet irradiation reduced incidence of healthcare-associated Clostridium difficile infection.






Entry filed under: Bacterias, Desinfection and Sterilization, Epidemiología, Health Care-Associated Infections, Infecciones en onco-hematologicos, Infecciones nosocomiales, Metodos diagnosticos, Update.

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