HIV-associated changes in the enteric microbial community – potential role in loss of homeostasis and development of systemic inflammation

February 3, 2017 at 1:33 pm

Current Opinion in Infectious Diseases February 2017  V.30 N.1 P.31-43

Gootenberg, David B.; Paer, Jeffrey M.; Luevano, Jesus-Mario

aRagon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Cambridge

bHarvard Medical School, Boston

cDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA

Correspondence to Douglas S. Kwon, MD, PhD, 400 Technology Square, Room 892, Cambridge, MA 02139, USA. Tel: +1 857 268 7009; e-mail: dkwon@mgh.harvard.edu

The enteric ‘microbiome’ consists of a diverse collection of trillions of Bacteria, Archaea, Eukarya, and viruses [1–5], with a large aggregate genome, referred to as the ‘metagenome’, that contributes to normal immune development [6] and a number of pathological processes [7–9].

The host immune system acts as an essential curator for this luminal enteric microbial community, serving to shape and control the structure and function of this diverse collection of organisms [10–12].

HIV infection leads to the widespread destruction of host immune function [13,14], including the rapid and profound depletion of CD4+ T cells within gut-associated lymphoid tissue …..

FULL TEXT

http://journals.lww.com/co-infectiousdiseases/Fulltext/2017/02000/HIV_associated_changes_in_the_enteric_microbial.6.aspx

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Entry filed under: HIV/SIDA, HIV/SIDA Trastornos GI.

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