Cytomegalovirus infection in inflammatory bowel disease is not associated with worsening of intestinal inflammatory activity.

February 9, 2017 at 2:47 pm

PLoS One. 2014 Nov 11;9(11):e111574.

do Carmo AM1, Santos FM1, Ortiz-Agostinho CL1, Nishitokukado I1, Frota CS1, Gomes FU1, Leite AZ1, Pannuti CS2, Boas LS3, Teixeira MG4, Sipahi AM1.

Author information

1Departamento de Gastroenterologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo – LIM 07, São Paulo, São Paulo, Brazil.

2Instituto de Medicina Tropical e Departamento de Doenças Infecciosas e Parasitarias (LIM-HC) da Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil.

3Instituto de Medicina Tropical e Hospital das Clínicas da Faculdade de Medicina (LIM-HC), Universidade de São Paulo, São Paulo, São Paulo, Brazil.

4Departamento de Cirurgia do Serviço de Cirurgia do Cólon Reto e Ânus, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil.

Erratum in

Correction: Cytomegalovirus Infection in Inflammatory Bowel Disease Is Not Associated with Worsening of Intestinal Inflammatory Activity. [PLoS One. 2015]

Abstract

BACKGROUND:

Cytomegalovirus is highly prevalent virus and usually occurs in immunocompromised patients. The pathophysiology and treatment of inflammatory bowel disease often induce a state of immunosuppression. Because this, there are still doubts and controversies about the relationship between inflammatory bowel disease and cytomegalovirus.

AIM:

Evaluate the frequency of cytomegalovirus in patients with inflammatory bowel disease and identify correlations.

METHODS:

Patients with inflammatory bowel disease underwent an interview, review of records and collection of blood and fecal samples. The search for cytomegalovirus was performed by IgG and IgM blood serology, by real-time PCR in the blood and by qualitative PCR in feces. Results were correlated with red blood cell levels, C-reactive protein levels, erythrocyte sedimentation rates and fecal calprotectin levels for each patient.

RESULTS:

Among the 400 eligible patients, 249 had Crohn’s disease, and 151 had ulcerative colitis. In the group of Crohn’s disease, 67 of the patients had moderate or severe disease, but 126 patients presented with active disease, based on the evaluation of the fecal calprotectin. In patients with ulcerative colitis, only 21 patients had moderate disease, but 76 patients presented with active disease, based on the evaluation of the fecal calprotectin. A large majority of patients had positive CMV IgG. Overall, 10 patients had positive CMV IgM, and 9 patients had a positive qualitative detection of CMV DNA by PCR in the feces. All 400 patients returned negative results after the quantitative detection of CMV DNA in blood by real-time PCR. Analyzing the 19 patients with active infections, we only found that such an association occurred with the use of combined therapy (anti-TNF-alpha + azathioprine).

CONCLUSION:

The findings show that latent cytomegalovirus infections are frequent and active cytomegalovirus infection is rare. We did not find any association between an active infection of CMV and inflammatory bowel disease activity

PDF

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227676/pdf/pone.0111574.pdf

 

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Entry filed under: Biología Molecular, Epidemiología, F.O.D, HIC no SIDA, Infecciones gastrointestinales, Infecciones virales, Metodos diagnosticos, Update.

Cytomegalovirus colitis with common variable immunodeficiency and Crohn’s disease. Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease.


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