Posterior Reversible Encephalopathy Syndrome and Fatal Cryptococcal Meningitis After Immunosuppression in a Patient With Elderly Onset Inflammatory Bowel Disease.

February 10, 2017 at 8:54 am

ACG Case Rep J. 2016 Aug 3;3(4):e98. eCollection 2016.

Vasant DH1, Limdi JK1, Borg-Bartolo SP1, Bonington A2, George R3.

Author information

1Department of Gastroenterology, Pennine Acute Hospitals NHS Trust, United Kingdom; Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom.

2Department of Infectious Diseases, Pennine Acute Hospitals NHS Trust, United Kingdom; Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom.

3Department of Gastroenterology, Pennine Acute Hospitals NHS Trust, United Kingdom.

Abstract

Advanced age and associated comorbidities are-recognized predictors of life-threatening adverse outcomes, such as opportunistic infection following immunosuppressive therapy.

We describe the case of an elderly patient with stricturing colonic Crohn’s disease and significant clinical comorbidities, initially controlled with corticosteroid induction followed by infliximab, whose course was complicated by fatal disseminated cryptococcal infection and posterior reversible encephalopathy syndrome.

Our patient’s case highlights rare, but serious, complications of immunosuppression.

In applying modern treatment paradigms to the elderly, the clinician must consider the potential for more pronounced adverse effects in this potentially vulnerable group, maximizing benefit and minimizing harm.

PDF

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062660/pdf/CG-CGCR160009.pdf

Advertisements

Entry filed under: Antimicoticos, Biológicos, Biología Molecular, F.O.D, HIC no SIDA, Infecciones del SNC, Infecciones en seniles, Infecciones micoticas, Metodos diagnosticos, Sepsis, Update.

Staphylococcus aureus bacteremia with iliac artery endarteritis in a patient receiving ustekinumab. Patients After Splenectomy: Old Risks and New Perspectives.


Calendar

February 2017
M T W T F S S
« Jan   Mar »
 12345
6789101112
13141516171819
20212223242526
2728  

Most Recent Posts


%d bloggers like this: