Accurate diagnosis and treatment of Vibrio vulnificus infection: a retrospective study of 12 cases.

February 17, 2017 at 4:41 pm

Braz J Infect Dis. 2013 Jan-Feb;17(1):7-12.

Matsuoka Y1, Nakayama Y, Yamada T, Nakagawachi A, Matsumoto K, Nakamura K, Sugiyama K, Tanigawa Y, Kakiuchi  Y, Sakaguchi Y.

Author information

1Department of Critical Care Medicine, Saga Medical School Hospital, Saga, Japan. yoshinori216@h2.dion.ne.jp

Abstract

BACKGROUND AND AIMS:

Vibrio vulnificus causes an infectious disease that has extremely poor convalescence and leads to necrotic fasciitis. In this study, we sought to define the characteristic epidemiology of V. vulnificus infection and clarify its diagnosis at the global level.

METHODS:

Over a period of 10 years, we investigated the appearance of symptoms, underlying conditions, treatment, and mortality in 12 patients (eight men, four women; >50 years old; average age, 66 years,) infected with V. vulnificus.

RESULTS:

The development of symptoms occurred primarily between June and September, a period during which seawater temperature rises and the prevalence of V. vulnificus increases. All patients had underlying diseases, and seven patients reported a history of consuming fresh fish and uncooked shellfish. The patients developed sepsis and fever with sharp pain in the limbs. Limb abnormalities were observed on visual examination. All patients underwent debridement; however, in the survival group, the involved limb was amputated early in 80% patients. The mortality rate was 58.3%.

CONCLUSION:

Recognition of the characteristic epidemiology and clinical features of this disease is important, and positive debridement should be performed on suspicion. When the illness reaches an advanced stage, however, amputation should be the immediate treatment of choice.

FULL TEXT (and PDF)

http://www.sciencedirect.com/science/article/pii/S141386701200219X

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Biología Molecular, Epidemiología, HIC no SIDA, Infecciones en piel y tej blandos, Infecciones en seniles, Metodos diagnosticos, REPORTS, Sepsis, Update.

Pre-existing medical conditions associated with Vibrio vulnificus septicaemia. Vibrio vulnificus DNA load and mortality.


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