Flow Cytometry To Assess Cerebrospinal Fluid Fungal Burden in Cryptococcal Meningitis

February 21, 2017 at 3:24 pm

Journal of Clinical Microbiology March 2016 V.54 N.3 P.802-804

Mycology

James E. Scriven, Lisa M. Graham, Charlotte Schutz, Thomas J. Scriba, Robert J. Wilkinson, David R. Boulware, Graeme Meintjes, David G. Lalloo, and Britta C. Urban

aLiverpool School of Tropical Medicine, Liverpool, Merseyside, United Kingdom

bWellcome Trust Liverpool Glasgow Centre for Global Health Research, Liverpool, United Kingdom

cClinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

dDepartment of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa

eSouth African TB Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa

fDepartment of Medicine, Imperial College, London, United Kingdom

gFrancis Crick Institute, Mill Hill Laboratory, London, United Kingdom

hDepartment of Medicine, University of Minnesota, Minnesota, USA

James E. Scriven, jscriven@liv.ac.uk

Fungal burden in the cerebrospinal fluid is an important determinant of mortality in cryptococcal meningitis, but its use in aiding clinical decision making is hampered by the time involved to perform quantitative cultures. Here, we demonstrate the potential of flow cytometry as a novel and rapid technique to address this issue.

PDF

http://jcm.asm.org/content/54/3/802.full.pdf

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Entry filed under: Antimicoticos, Biología Molecular, Epidemiología, Infecciones del SNC, Metodos diagnosticos, Sepsis, Update.

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