Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance

February 23, 2017 at 7:52 am

Antimicrobial Agents and Chemotherapy April 2016 V.60 N.4 P.2524-2527

Michael J. Bottery, A. Jamie Wood, and Michael A. Brockhurst

aDepartment of Biology, University of York, York, United Kingdom

bDepartment of Mathematics, University of York, York, United Kingdom

Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance.

We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.

PDF

http://aac.asm.org/content/60/4/2524.full.pdf

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Biología Molecular, Epidemiología, Metodos diagnosticos, Resistencia bacteriana, Sepsis, Update.

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