Nosocomial Outbreak of Drug-Resistant Streptococcus pneumoniae Serotype 9V in an Adult Respiratory Medicine Ward

February 24, 2017 at 7:59 am

Journal of Clinical Microbiology March 2017 V.55 N.3 P.776-782

Elita Jauneikaite, Zareena Khan-Orakzai, Georgia Kapatai, Susannah Bloch, Julie Singleton, Sara Atkin, Victoria Shah, James Hatcher, Dunisha Samarasinghe, Carmen Sheppard, Norman K. Fry, Giovanni Satta, and Shiranee Sriskandan

aHealth Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, United Kingdom

bDepartment of Medicine, Imperial College London, London, United Kingdom

cImperial College Healthcare NHS Trust, London, United Kingdom

dRespiratory and Vaccine Preventable Bacteria Reference Unit, Public Health England, National Infection Service, Colindale, London, United Kingdom

eNorth West London Health Protection Team, Public Health England, London, United Kingdom

fCentre for Clinical Microbiology, University College London, London, United Kingdom

Streptococcus pneumoniae infections arising in hospitalized patients are often assumed to be sporadic and linked to community acquisition.

Here, whole-genome sequencing was used to demonstrate nosocomial acquisition of antimicrobial-resistant sequence type 156 (ST156) serotype 9V S. pneumoniae in 3 respiratory patients that resulted in two bacteremias and one lower respiratory tract infection.

Two of the cases arose in patients who had recently been discharged from the hospital and were readmitted from the community.

Nosocomial spread was suspected solely because of the highly unusual resistance pattern and case presentations within 24 h of one another.

The outbreak highlights the potential for rapid transmission and the short incubation period in the respiratory ward setting.



Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Epidemiología, Infecciones respiratorias, Inmunizaciones, Metodos diagnosticos, Resistencia bacteriana, Sepsis, Update.

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