Streptococcus pyogenes Pneumonia in Adults: Clinical Presentation and Molecular Characterization of Isolates 2006-2015.

February 25, 2017 at 1:26 pm

PLoS One. 2016 Mar 30;11(3):e0152640.

Tamayo E1, Montes M1,2, Vicente D1,2, Pérez-Trallero E1,2,3.

Author information

1Biomedical Research Center Network for Respiratory Diseases (CIBERES), San Sebastián, Spain.

2Microbiology Department, Hospital Universitario Donostia-Instituto Biodonostia, San Sebastián, Spain.

3Medicine Faculty, University of the Basque Country, UPV/EHU, San Sebastián, Spain.

Abstract

INTRODUCTION:

In the preantibiotic era Streptococcus pyogenes was a common cause of severe pneumonia but currently, except for postinfluenza complications, it is not considered a common cause of community-acquired pneumonia in adults.

AIM AND MATERIAL AND METHODS:

This study aimed to identify current clinical episodes of S. pyogenes pneumonia, its relationship with influenza virus circulation and the genotypes of the involved isolates during a decade in a Southern European region (Gipuzkoa, northern Spain). Molecular analysis of isolates included emm, multilocus-sequence typing, and superantigen profile determination.

RESULTS:

Forty episodes were detected (annual incidence 1.1 x 100,000 inhabitants, range 0.29-2.29). Thirty-seven episodes were community-acquired, 21 involved an invasive infection and 10 developed STSS. The associated mortality rate was 20%, with half of the patients dying within 24 hours after admission. Influenza coinfection was confirmed in four patients and suspected in another. The 52.5% of episodes occurred outside the influenza seasonal epidemic. The 67.5% of affected persons were elderly individuals and adults with severe comorbidities, although 13 patients had no comorbidities, 2 of them had a fatal outcome. Eleven clones were identified, the most prevalent being emm1/ST28 (43.6%) causing the most severe cases.

CONCLUSIONS:

  1. pyogenes pneumonia had a continuous presence frequently unrelated to influenza infection, being rapidly fatal even in previously healthy individuals.

PDF

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814053/pdf/pone.0152640.pdf

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Biología Molecular, Epidemiología, Infecciones respiratorias, Metodos diagnosticos, Sepsis, Update.

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