Clinical characteristics of primary Epstein Barr virus hepatitis with elevation of alkaline phosphatase and γ-glutamyltransferase in children.

March 1, 2017 at 3:33 pm

Yonsei Med J. 2014 Jan;55(1):107-12. 

Yang SI1, Geong JH, Kim JY.

Author information

1Department of Pediatrics, School of Medicine, Chungnam National University, 282 Munhwa-ro, Jung-gu, Daejeon 301-721, Korea. pedkim@cnuh.co.kr

Abstract

PURPOSE:

The aim of the present study was to evaluate the clinical characteristics of the primary Epstein-Barr virus (EBV) hepatitis with elevation of both serum alkaline phosphatase (ALP) and γ-glutamyltransferase (γ-GT) levels in children.

MATERIALS AND METHODS:

A retrospective study was performed by reviewing of the medical records of 36 patients who were diagnosed with primary EBV hepatitis. The patients were divided into 2 groups: patients with elevated serum ALP and γ-GT levels (group 1) and patients without (group 2).

RESULTS:

The classic features of infectious mononucleosis (fever, pharyngitis and/or tonsillitis, and cervical lymphadenitis) were seen in 20 (57.1%) of group 1 patients and 18 (50.0%) of group 2 patients. Hepatitis with elevated serum ALP and γ-GT levels were present in 14 (38.9%) of the all patients. Of these patients, Jaundice occurred in only 2 (5.6%). The mean levels of aspartate aminotransferase and alanine aminotransferase (ALT) as well as the number of patients with ALT greater than 400 IU/L were significantly different between the groups (177 IU/L vs. 94 IU/L, 418 IU/L vs. 115 IU/L, and 50.0% vs. 13.6%; p=0.001, p=0.001, p=0.026, respectively). The mean duration of elevated serum ALT levels was 17.5 days in group 1 and 9.0 days in group 2 (p=0.013). All patients recovered fully without any chronic or serious complications.

CONCLUSION:

Primary EBV hepatitis with predominant biochemical abnormalities of the elevation of ALP and γ-GT is frequent and mostly anicteric. This may represent a benign disease, but a delay in recovery of liver function as well.

PDF

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874904/pdf/ymj-55-107.pdf

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Entry filed under: Biología Molecular, Epidemiología, F.O.D, FIEBRE y RASH, Infecciones virales, Metodos diagnosticos, Update.

Clinical and laboratory differences between Epstein-Barr and cytomegalovirus infectious mononucleosis in children. Acyclovir reduces the duration of fever in patients with infectious mononucleosis-like illness.


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