Concentration-Dependent Antagonism and Culture Conversion in Pulmonary Tuberculosis

May 6, 2017 at 3:53 pm

Clin Inf Dis May 15, 2017 V.64 N.10

Neesha Rockwood; Jotam G. Pasipanodya; Paolo Denti; Frederick Sirgel; Maia Lesosky

The relationship between drug concentrations, minimum inhibitory concentrations, and sputum culture conversion in tuberculosis is unclear. We identified concentration-dependent antagonism between isoniazid and rifampicin that was associated with poorer 2-month sputum conversion.

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https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/cid/64/10/10.1093_cid_cix158/2/cix158.pdf?Expires=1494188795&Signature=TeTh9nAC4CxyRjW-XRWYyEgZQgrkAXh3bcVJvUvSPB-JgDO4OxZ-uZ08IyqLaNonrvSJNc75eAR-InIa7LvO9tI2~jQX2gRjY8wsnR6ZyhcwNrb2pYlRGE4C1mRh3UINsfF4vEADoUKGNwG1bBYfCeT-ymbqVDacJtRReXMhX1NJrSLyq8ie8KNdBBmhkJAFF86LiGnJEiQLpwRei~eNdyVZhOQQzetL0dVwcZnXLHmPyO9Z4dF-uW0U~LZVkpG8~L4-iMlT07~WZHvbYr~TB3KILDi5bhY1x2b-JBU1z~MRqkEK0NqIFRaxwWOssktJYqpPibUt9TJw6jHBbKQVdA__&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q

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Entry filed under: Infecciones respiratorias, Metodos diagnosticos, Micobacterias, Sepsis, Update.

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