Guidelines – Recommendations on hepatitis C screening for adults

May 9, 2017 at 3:35 pm

Canadian Medical Journal Association April 24, 2017 V.189 N.16

Canadian Task Force on Preventive Health Care

An estimated 0.64%–0.71% of Canadians (220 000–245 000 people) have chronic hepatitis C virus (HCV) infection,1 and approximately 44%2 of those may be undiagnosed. HCV can be transmitted directly through percutaneous exposure (e.g., through inadequately sterilized medical equipment) or through receipt of contaminated blood products.3 People who inject drugs are at highest risk, but recipients of unscreened blood products, tissues or organs and patients undergoing long-term hemodialysis are also at increased risk.3 Less common modes of transmission include vertical transmission, high-risk sexual contact, unsterilized tattoo or piercing equipment, and occupational exposure.3 Not all people with chronic HCV infection will develop cirrhosis or signs or symptoms indicative of liver disease.4 It is estimated that approximately 84% of people infected with HCV do not develop cirrhosis 20 years after acute infection, and 59% after 30 years.5,6 Progression of liver fibrosis is variable and influenced by factors such as alcohol consumption, age at time of infection, male sex and HIV coinfection.7

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http://www.cmaj.ca/content/189/16/E594.full.pdf+html

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Entry filed under: Biología Molecular, Epidemiología, GUIDELINES, Hepatitis C, Infecciones virales, Metodos diagnosticos, Update.

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