Use of Chlorhexidine Preparations in Total Joint Arthroplasty.

June 20, 2017 at 2:21 pm

J Bone Jt Infect. 2017 Jan 1;2(1):15-22.

George J1, Klika AK1, Higuera CA1.

Author information

1 Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA.

Abstract

Prosthetic joint infection (PJI) is a serious complication after total joint arthroplasty (TJA). Chlorhexidine is a widely used antiseptic because of its rapid and persistent action. It is well tolerated and available in different formulations at various concentrations. Chlorhexidine can be used for pre-operative skin cleansing, surgical site preparation, hand antisepsis of the surgical team and intra-articular irrigation of infected joints. The optimal intra-articular concentration of chlorhexidine gluconate in irrigation solution is 2%, to provide a persistent decrease in biofilm formation, though cytotoxicity might be an issue. Although chlorhexidine is relatively cheap, routine use of chlorhexidine without evidence of clear benefits can lead to unnecessary costs, adverse effects and even emergence of resistance. This review focuses on the current applications of various chlorhexidine formulations in TJA. As the treatment of PJI is challenging and expensive, effective preparations of chlorhexidine could help in the prevention and control of PJI.

PDF

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423571/pdf/jbjiv02p0015.pdf

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Entry filed under: Bacterias, Desinfection and Sterilization, Epidemiología, Health Care-Associated Infections, Infecciones nosocomiales, Infecciones osteo-articulares-musculares, Infecciones relacionadas a prótesis, Infecciones sitio quirurgico, Metodos diagnosticos, Profilaxis Antibiótica en Cirugía - PAC, REPORTS, Update.

Treatment of Periprosthetic Joint Infection Using Antimicrobials: Dilute Povidone-Iodine Lavage. Candida Prosthetic Joint Infection. A Review of Treatment Methods.


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