Staphylococcus capitis isolated from prosthetic joint infections.

June 22, 2017 at 5:54 pm

Eur J Clin Microbiol Infect Dis. Jan 2017 V.36 N.1 P.115-122.

Tevell S1,2, Hellmark B3, Nilsdotter-Augustinsson Å4, Söderquist B5.

Author information

1 Department of Infectious Diseases, Karlstad Hospital, Karlstad, Sweden. staffan.tevell@liv.se

2 School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. staffan.tevell@liv.se

3 Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

4 Department of Infectious Diseases and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

5 School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Abstract

Further knowledge about the clinical and microbiological characteristics of prosthetic joint infections (PJIs) caused by different coagulase-negative staphylococci (CoNS) may facilitate interpretation of microbiological findings and improve treatment algorithms. Staphylococcus capitis is a CoNS with documented potential for both human disease and nosocomial spread. As data on orthopaedic infections are scarce, our aim was to describe the clinical and microbiological characteristics of PJIs caused by S. capitis. This retrospective cohort study included three centres and 21 patients with significant growth of S. capitis during revision surgery for PJI between 2005 and 2014. Clinical data were extracted and further microbiological characterisation of the S. capitis isolates was performed. Multidrug-resistant (≥3 antibiotic groups) S. capitis was detected in 28.6 % of isolates, methicillin resistance in 38.1 % and fluoroquinolone resistance in 14.3 %; no isolates were rifampin-resistant. Heterogeneous glycopeptide-intermediate resistance was detected in 38.1 %. Biofilm-forming ability was common. All episodes were either early post-interventional or chronic, and there were no haematogenous infections. Ten patients experienced monomicrobial infections. Among patients available for evaluation, 86 % of chronic infections and 70 % of early post-interventional infections achieved clinical cure; 90 % of monomicrobial infections remained infection-free. Genetic fingerprinting with repetitive sequence-based polymerase chain reaction (rep-PCR; DiversiLab®) displayed clustering of isolates, suggesting that nosocomial spread might be present. Staphylococcus capitis has the potential to cause PJIs, with infection most likely being contracted during surgery or in the early postoperative period. As S. capitis might be an emerging nosocomial pathogen, surveillance of the prevalence of PJIs caused by S. capitis could be recommended.

PDF

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203848/pdf/10096_2016_Article_2777.pdf

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Entry filed under: Antimicrobianos, Bacterias, Epidemiología, FIEBRE en el POSTOPERATORIO, Health Care-Associated Infections, Infecciones nosocomiales, Infecciones osteo-articulares-musculares, Infecciones relacionadas a prótesis, Infecciones sitio quirurgico, Metodos diagnosticos, Profilaxis Antibiótica en Cirugía - PAC, REPORTS, Sepsis, Update.

Distribution characteristics of Staphylococcus spp. in different phases of periprosthetic joint infection: A review. Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority study


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