Tigecycline treatment in an infant with extensively drug-resistant Acinetobacter baumannii bacteremia

June 25, 2017 at 1:39 pm

International Journal of Infectious Diseases August 2017 V.61 P.23–26

Jiawei Zeng, Lidan Zhang, Min Gao, Jingjing Wu, Haiyan Wu, Jie Chen, Xiao Chen, Wen Tang

Highlights

  • A case of extensively drug-resistant Acinetobacter baumannii bacteremia in an immunocompetent infant is reported.
  • Tigecycline was used successfully with monitoring of trough serum concentrations to address its safety, efficacy, and pharmacokinetics.
  • This is the first report of tigecycline monitoring in a pediatric patient with bloodstream infection​, and it is worth monitoring drug concentrations.
  • This is the youngest case treated with tigecycline for A. baumannii bacteremia according to the published literature.
  • Tigecycline can be given for life-threatening infections in children for whom no better alternative antimicrobial options are available.

The successful use of tigecycline in a 12-month old liver transplant recipient with extensively drug-resistant Acinetobacter baumannii bacteremia is presented.

Tigecycline serum concentrations were monitored to help improve antibiotic efficacy and minimize side effects.

A literature review identified 11 additional pediatric cases of A. baumannii infection treated with tigecycline since 2011.

Tigecycline treatment should be considered in children with extensively drug-resistant bacterial infections.

PDF

http://www.ijidonline.com/article/S1201-9712(17)30149-2/pdf

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Metodos diagnosticos, Resistencia bacteriana, Sepsis, Update.

Actividad comparativa in vitro entre linezolid y tedizolid frente a aislados clínicos de Staphylococcus aureus resistentes a meticilina y aislados resistentes también a linezolid Risk Factors for 30-Day Mortality in Patients with Methicillin-Resistant Staphylococcus aureus Bloodstream Infections


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