Pharmacokinetics of ertapenem following intravenous and subcutaneous infusions in patients.

July 2, 2017 at 2:17 pm

Antimicrob Agents Chemother. 2010 Feb;54(2):924-6.       

Frasca D1, Marchand S, Petitpas F, Dahyot-Fizelier C, Couet W, Mimoz O.

Author information

1 INSERM, ERI-23, Pôle Biologie Santé, 40 Avenue du Recteur Pineau, Poitiers, France.

Abstract

Steady-state pharmacokinetics of ertapenem were compared in patients after 1-g intravenous and subcutaneous (s.c.) infusions.

Bioavailability was 99%+/-18% after s.c. administration, but peaks were reduced by about (43+/-29 versus 115+/-28 microg/ml) and times to peak were delayed.

Simulations based on unbound concentrations show that time over the MIC should always be longer than 30% to 40% of the dosing interval, suggesting that s.c. infusion could be an alternative in patients with reduced vascular acces …

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http://aac.asm.org/content/54/2/924.full.pdf+html

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Metodos diagnosticos, REPORTS, Sepsis, Update.

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