Resistance to Colistin in Klebsiella Pneumoniae: A 4.0 Strain?

July 2, 2017 at 9:29 pm

Infect Dis Rep. May 31, 2017 V.9 N.2 P.7104.     

Granata G1, Petrosillo N1.

Author information

1 Clinical and Research Department, National Institute for Infectious Diseases “L. Spallanzani” – IRCCS, Rome, Italy.

Abstract

The global rise of multidrug-resistant gram-negative bacteria represents an increasing threat to patient safety. From the first observation of a carbapenem-resistant gram-negative bacteria a global spread of extended-spectrum beta-lactamases and carbapenemases producing Klebsiella pneumoniae has been observed.

Treatment options for multidrug-resistant K. pneumoniae are actually limited to combination therapy with some aminoglycosides, tigecycline and to older antimicrobial agents. Unfortunately, the prevalence of colistin-resistant and tigecycline-resistant K. pneumoniae is increasing globally. Infection due to colistin-resistant K. pneumoniae represents an independent risk factor for mortality.

Resistance to colistin in K. pneumoniae may be multifactorial, as it is mediated by chromosomal genes or plasmids. The emergence of transmissible, plasmid-mediated colistin resistance is an alarming finding.

The absence of new agents effective against resistant Gram-negative pathogens means that enhanced surveillance, compliance with infection prevention procedures, and antimicrobial stewardship programs will be required to limit the spread of colistin-resistant K. pneumoniae.

PDF

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472342/pdf/idr-9-2-7104.pdf

 

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Epidemiología, Health Care-Associated Infections, Infecciones emergentes, Infecciones nosocomiales, Metodos diagnosticos, REPORTS, Resistencia bacteriana, Sepsis, Update.

Pharmacokinetics of ertapenem following intravenous and subcutaneous infusions in patients. The efficacy and safety of tigecycline for the treatment of bloodstream infections: a systematic review and meta-analysis.


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