Coagulase-negative staphylococci.

July 6, 2017 at 9:55 pm

Clin Microbiol Rev. October 2014 V.27 N.4 P.870-926.                         

Becker K1, Heilmann C2, Peters G2.

Author information

1 Institute of Medical Microbiology, University Hospital Münster, Münster, Germany kbecker@uni-muenster.de.

2 Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Abstract

The definition of the heterogeneous group of coagulase-negative staphylococci (CoNS) is still based on diagnostic procedures that fulfill the clinical need to differentiate between Staphylococcus aureus and those staphylococci classified historically as being less or nonpathogenic.

Due to patient- and procedure-related changes, CoNS now represent one of the major nosocomial pathogens, with S. epidermidis and S. haemolyticus being the most significant species. They account substantially for foreign body-related infections and infections in preterm newborns.

While S. saprophyticus has been associated with acute urethritis, S. lugdunensis has a unique status, in some aspects resembling S. aureus in causing infectious endocarditis.

In addition to CoNS found as food-associated saprophytes, many other CoNS species colonize the skin and mucous membranes of humans and animals and are less frequently involved in clinically manifested infections.

This blurred gradation in terms of pathogenicity is reflected by species- and strain-specific virulence factors and the development of different host-defending strategies.

Clearly, CoNS possess fewer virulence properties than S. aureus, with a respectively different disease spectrum. In this regard, host susceptibility is much more important.

Therapeutically, CoNS are challenging due to the large proportion of methicillin-resistant strains and increasing numbers of isolates with less susceptibility to glycopeptides.

PDF

http://cmr.asm.org/content/27/4/870.full.pdf+html

Advertisements

Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Metodos diagnosticos, REPORTS, Resistencia bacteriana, REVIEWS, Sepsis, Update.

EDITORIAL – Estafilococos coagulasa negativos: el enemigo silente Determining the burden of respiratory syncytial virus disease: the known and the unknown


Calendar

July 2017
M T W T F S S
« Jun   Aug »
 12
3456789
10111213141516
17181920212223
24252627282930
31  

Most Recent Posts


%d bloggers like this: