Recent advances in understanding Epstein-Barr virus.

July 25, 2017 at 7:50 pm

F1000Res. 2017 Mar 29;6:386.

Stanfield BA1, Luftig MA1.

Author information

1 Department of Molecular Genetics and Microbiology, Duke Center for Virology, Duke University Medical Center, Durham, NC, USA.

Abstract

Epstein-Barr virus (EBV) is a common human herpes virus known to infect the majority of the world population.

Infection with EBV is often asymptomatic but can manifest in a range of pathologies from infectious mononucleosis to severe cancers of epithelial and lymphocytic origin. Indeed, in the past decade, EBV has been linked to nearly 10% of all gastric cancers.

Furthermore, recent advances in high-throughput next-generation sequencing and the development of humanized mice, which effectively model EBV pathogenesis, have led to a wealth of knowledge pertaining to strain variation and host-pathogen interaction.

This review highlights some recent advances in our understanding of EBV biology, focusing on new findings on the early events of infection, the role EBV plays in gastric cancer, new strain variation, and humanized mouse models of EBV infection.

PDF

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373418/pdf/f1000research-6-11413.pdf

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Entry filed under: ADENOPATIAS - LINFADENITIS, Biología Molecular, Epidemiología, F.O.D, Infecciones virales, Metodos diagnosticos, REPORTS, REVIEWS, Update.

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