A case report of intraventricular tigecycline therapy for intracranial infection with extremely drug resistant A baumannii.

August 5, 2017 at 9:15 am

MEDICINE August 2017 V.96 N.31

Fang, Yu-Qing MDa; Zhan, Ru-Cai MDb; Jia, Wei MDc; Zhang, Bao-Qing MMd; Wang, Jian-Jun MDb,*

Section Editor(s): Rosca., Elena Cecilia

Rationale

Intracranial infection with Acinetobacter baumannii is a tough problem due to the presence of multiresistance and drugs poor penetration through the blood brain barrier (BBB). Tigecycline is effective to cure A baumannii, but it can only be used intravenously which is also difficult to pass BBB. So, it will be a breakthrough if intraventricular (IVT) tigecycline is used in the clinical therapy. However, this treatment has been reported quite rarely until now.

Patient concerns

We described a case of a 50-year-old male worker whose clinical futures were high fever and cerebral rigidity after neurosurgery.

Diagnoses

Intracranial infection with extensive drug resistant (XDR) A baumannii.

Interventions

The patient was treated with IVT tigecycline.

Outcomes

The symptoms of intracranial infection disappeared. The temperature of this patient decreased to normal and cerebral rigidity disappeared. The cerebrospinal fluid culture became negative, with normal levels of white blood cell, glucose and chlorine.

Lessons

IVT tigecycline therapy maybe effective to intracranial infection with XDR A baumannii. However, more studies will further demonstrate the therapeutic values of IVT tigecycline to intracranial infection, and not only restricted to A baumannii infections.

FULL TEXT

http://journals.lww.com/md-journal/Fulltext/2017/08040/A_case_report_of_intraventricular_tigecycline.41.aspx

Advertisements

Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Epidemiología, FIEBRE en el POSTOPERATORIO, Health Care-Associated Infections, Infecciones del SNC, Infecciones nosocomiales, Metodos diagnosticos, REPORTS, Resistencia bacteriana, Sepsis, Update.

Polymerase Chain Reaction – An Important Tool for Early Diagnosis of Leptospirosis Cases. Candida vertebral osteomyelitis (CVO) 28 cases from a 10-year retrospective study in France


Calendar

August 2017
M T W T F S S
« Jul    
 123456
78910111213
14151617181920
21222324252627
28293031  

Most Recent Posts


%d bloggers like this: