Candida vertebral osteomyelitis (CVO) 28 cases from a 10-year retrospective study in France

August 5, 2017 at 9:18 am

MEDICINE August 2017 V.96 N.31

Richaud, Clémence; De Lastours, Victoire; Panhard, Xavière; Petrover, David; Bruno, Fantin; Lefort, Agnès


Although increasingly frequent, little is known about the clinical presentation, radiological signs, and outcome of Candida vertebral osteomyelitis (CVO).

We performed a nationwide retrospective study of laboratory-confirmed cases of CVO over a 10 year-period in France with a prolonged follow-up.

We describe demographic, clinical, biological, and radiological characteristics of patients with CVO, patients’ management, and long-term outcome and determine factors associated with a poor outcome.

In total, 28 patients with laboratory-confirmed CVO were included. A prior systemic Candida infection was evidenced in 13/28 (46%), occurring a median of 6 weeks before CVO was diagnosed.

Twenty-six of 28 (93%) had at least 1 underlying condition at risk of invasive fungal disease, and in 19/28 (68%) CVO was health-care related.

C albicans was most frequently identified (21/28; 75%) Lumbo-sacral involvement was the most prevalent (20/28—71%). Nearly half patients had no fever at presentation, but all had pain.

Initial antifungal therapy consisted in fluconazole in 15/28 (53%); surgery was needed in 5 (18%) cases.

One-year mortality was 21% (6/28), directly related to fungal infection in 2 patients.

Risk-factors associated with 1-year mortality were age (P=.02), a high Charlson comorbidity index (P = .001), and a shorter treatment duration (median, 3 months vs 6 months; P = .02).

Among 22 patients who survived, the median follow up duration was 15.5 months (8–93.5); 10 had sequelae, consisting in pain in all and neurological deficit in one.

A longer treatment duration was significantly associated with healing without sequelae (P = .04).

CVO concerns patients with serious underlying conditions and risk-factors for invasive candidiasis.

Prolonged antifungal treatment appears to improve survival without sequelae.



Entry filed under: Antimicoticos, Biología Molecular, Epidemiología, Health Care-Associated Infections, Infecciones micoticas, Infecciones nosocomiales, Infecciones osteo-articulares-musculares, Metodos diagnosticos, REPORTS, Sepsis.

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