Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype

August 11, 2017 at 9:13 am

Journal of Antimicrobial Chemotherapy August 2017 V.72 N.8 P.2145–2155

EDITOR’S CHOICE

Edward R. Bevan; Annie M. Jones; Peter M. Hawkey

Globally, rates of ESBL-producing Enterobacteriaceae are rising. We undertook a literature review, and present the temporal trends in blaCTX-M epidemiology, showing that blaCTX-M-15 and blaCTX-M-14 have displaced other genotypes in many parts of the world.

Explanations for these changes can be attributed to:

(i) horizontal gene transfer (HGT) of plasmids;

(ii) successful Escherichia coli clones;

(iii) ESBLs in food animals;

(iv) the natural environment; and

(v) human migration and access to basic sanitation.

We also provide explanations for the changing epidemiology of blaCTX-M-2 and blaCTX-M-27.

Modifiable anthropogenic factors, such as poor access to basic sanitary facilities, encourage the spread of blaCTX-M and other antimicrobial resistance (AMR) genes, such as blaNDM, blaKPC and mcr-1.

We provide further justification for novel preventative and interventional strategies to reduce transmission of these AMR genes.

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Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Biología Molecular, Epidemiología, Metodos diagnosticos, Resistencia bacteriana, Sepsis, Update.

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