In vitro activity of tedizolid and linezolid against Staphylococcus epidermidis isolated from prosthetic joint infections

August 22, 2017 at 8:25 am

European Journal of Clinical Microbiology & Infectious Diseases September 2017 V.36 N.9 P. 1549–1552

Littorin, B. Hellmark, Å. Nilsdotter-Augustinsson & B. Söderquist

1.School of Medical Sciences, Faculty of Medicine and HealthÖrebro UniversityÖrebroSweden

2.Department of Laboratory Medicine, Clinical MicrobiologyÖrebro University HospitalÖrebroSweden

3.Division of Infectious Diseases, Department of Clinical and Experimental Medicine, Faculty of Health SciencesLinköping UniversityLinköpingSweden

4.Department of Infectious DiseasesCounty Council of ÖstergötlandLinköpingSweden

5.Departments of Infectious Diseases and Laboratory Medicine, Clinical MicrobiologyÖrebro University HospitalÖrebroSweden

Prosthetic joint infections (PJIs) are rare but long-lasting and are serious complications without any spontaneous resolution, requiring additional surgery and long-term treatment with antibiotics.

Staphylococci are the most important aetiological agents of PJIs, and among the coagulase-negative staphylococci Staphylococcus epidermidis is the most common.

However, S. epidermidis often displays multidrug resistance (MDR), demanding additional treatment options.

The objective was to examine the effectiveness of tedizolid and linezolid against S. epidermidis isolated from PJIs. The standard antibiotic susceptibility pattern of S. epidermidis (n = 183) obtained from PJIs was determined by disc diffusion test, and MIC was determined by Etest for tedizolid, linezolid, and vancomycin.

Tedizolid displayed MIC values ranging from 0.094 to 0.5 mg/L (MIC50: 0.19 mg/L, MIC90: 0.38 mg/L), linezolid MIC values ranging from 0.25 to 2 mg/L (MIC50: 0.75 mg/L, MIC90: 1 mg/L), and vancomycin MIC values ranging from 0.5 to 3 mg/L (MIC50 and MIC90 both 2 mg/L).

According to the disc diffusion test, 153/183 (84%) isolates were resistant to ≥3 antibiotic groups, indicating MDR.

In conclusion, S. epidermidis isolates from PJIs were fully susceptible, and the MIC50 and MIC90 values for tedizolid were two- to four-fold dilution steps lower compared with linezolid.

Tedizolid is not approved, and there are no reports of long-term treatment, but it may display better tolerability and fewer adverse effects than linezolid; it thus could be a possible treatment option for PJIs, alone or in combination with rifampicin.

abstract

https://link.springer.com/article/10.1007/s10096-017-2966-z?wt_mc=alerts.TOCjournals

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Entry filed under: Antimicrobianos, Bacterias, Epidemiología, FIEBRE en el POSTOPERATORIO, Health Care-Associated Infections, Infecciones nosocomiales, Infecciones osteo-articulares-musculares, Infecciones relacionadas a prótesis, Infecciones sitio quirurgico, Metodos diagnosticos, REPORTS, Resistencia bacteriana, Sepsis, Update.

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