Extensive colonization with carbapenemase-producing microorganisms in Romanian burn patients: infectious consequences from the Colectiv fire disaster

January 7, 2018 at 10:12 am

European Journal of Clinical Microbiology & Infectious Diseases January 2018 V.37 N.1 P.175–183

E. Pirii, A. W. Friedrich, J. W.A. Rossen, W. Vogels, G. I. J. M. Beerthuizen, M. K. Nieuwenhuis, A. M. D. Kooistra-Smid & E. Bathoorn

Health care of severe burn patients is highly specialized and may require international patient transfer. Burn patients have an increased risk of developing infections. Patients that have been hospitalized in countries where carbapenemase-producing microorganisms (CPMO) are endemic may develop infections that are difficult to treat. In addition, there is a risk on outbreaks with CPMOs in burn centers.

This study underlines that burn patients may extensively be colonized with CPMOs, and it provides best practice recommendations regarding clinical microbiology and infection control.

We evaluated CPMO-carriage and wound colonization in a burn patient initially treated in Romania, and transported to the Netherlands.

The sequence types and acquired beta-lactamase genes of highly-resistant microorganisms were derived from next generation sequencing data.

Next, we searched literature for reports on CPMOs in burn patients.

Five different carbapenemase-producing isolates were cultured: two unrelated OXA-48-producing Klebsiella pneumoniae isolates, OXA-23-producing Acinetobacter baumanii, OXA-48-producing Enterobacter cloacae, and NDM-1-producing Providencia stuartii.

Also, multi-drug resistant Pseudomonas aeruginosa isolates were detected. Among the sampling sites, there was high variety in CPMOs. We found 46 reports on CPMOs in burn patients.

We listed the epidemiology of CPMOs by country of initial treatment, and summarized recommendations for care of these patients based on these reports and our study.

abstract

https://link.springer.com/article/10.1007/s10096-017-3118-1?wt_mc=alerts.TOCjournals

PDF

https://link.springer.com/content/pdf/10.1007%2Fs10096-017-3118-1.pdf

 

Advertisements

Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Biología Molecular, Epidemiología, Metodos diagnosticos, REPORTS, Resistencia bacteriana, Sepsis, Update.

Dental procedures, antibiotic prophylaxis, and endocarditis among people with prosthetic heart valves: Nationwide population based cohort and a case crossover study 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea


Calendar

January 2018
M T W T F S S
« Dec   Feb »
1234567
891011121314
15161718192021
22232425262728
293031  

Most Recent Posts


%d bloggers like this: