Predictors of pneumonia in lower respiratory tract infections: 3C prospective cough complication cohort study.

January 16, 2018 at 11:01 am

European Respiratory Journal November 22, 2017 V.50 N.5   

Moore M1, Stuart B2, Little P2, Smith S3, Thompson MJ4, Knox K3, van den Bruel A3, Lown M2, Mant D3.

Author information

1 University of Southampton, Primary Care Medical Group, Aldermoor Health Centre, Southampton, UK

2 University of Southampton, Primary Care Medical Group, Aldermoor Health Centre, Southampton, UK.

3 Nuffield Department of Primary Health Care Sciences, University of Oxford, Oxford, UK.

4 Dept of Family Medicine, University of Washington, Seattle, WA, USA.


The aim was to aid diagnosis of pneumonia in those presenting with lower respiratory tract symptoms in routine primary care.A cohort of 28 883 adult patients with acute cough attributed to lower respiratory tract infections (LRTIs) was recruited from 5222 UK practices in 2009-13. Symptoms, signs and treatment were recorded at presentation and subsequent events followed-up for 30 days by chart review. The predictive value of patient characteristics, presenting symptoms and clinical findings for the diagnosis of pneumonia in the first 7 days was established.Of the 720 out of 28 883 (2.5.%) radiographed within 1 week of the index consultation, 115 (16.0%; 0.40% of 28 883) were assigned a definite or probable pneumonia diagnosis. The significant independent predictors of radiograph-confirmed pneumonia were temperature >37.8°C (RR 2.6; 95% CI 1.5-4.8), crackles on auscultation (RR 1.8; 1.1-3.0), oxygen saturation <95% (RR 1.7; 1.0-3.1) and pulse >100·min-1 (RR 1.9; 1.1-3.2). Most patients with pneumonia (99/115, 86.1%) exhibited at least one of these four clinical signs; the positive predictive value of having at least one of these signs was 20.2% (95% CI 17.3-23.1).In routine practice, radiograph-confirmed pneumonia as a short-term complication of LRTI is very uncommon (one in 270). Pulse oximetry may aid the diagnosis of pneumonia in this setting.



Entry filed under: Infecciones respiratorias, Metodos diagnosticos, REPORTS, Sepsis, Update.

Risk of acute kidney injury in patients on concomitant VANCO and P-TAZO compared to those on VANCO and cefepime. Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.


January 2018
« Dec   Feb »

Most Recent Posts

%d bloggers like this: