Archive for February 2, 2018

A Comparison of Nephrotoxicity in Non–Intensive Care Unit Medical/Surgical Patients Receiving Vancomycin Alone Versus Vancomycin With Piperacillin-Tazobactam—Do We Need to Ban this combination?

Infectious Diseases in Clinical Practice January 2018 V.26 N.1 P.1-2

Editorial Comment

Tulkens, Paul M.; Written as an editorial commentary regarding Eberle et al.

A Comparison of Nephrotoxicity in Non–Intensive Care Unit Medical-Surgical Patients Receivi Eberle et al1 from Regional One Health in Memphis, Tennessee, publish in this issue of the journal a study where they examined whether associating piperacillin/tazobactam to vancomycin will increase nephrotoxicity of this old but still widely trusted glycopeptide.

The study, which is retrospective and from a single institution, enrolled 198 evaluable patients (out of a total of 867 retained in a first round of selection) over a period of 6 months in 2015 to 2016.

The results are straightforward, with vancomycin-attributable nephrotoxicity rising from 5.6% to 18.4% when comparing patients receiving vancomycin only versus those with combination therapy.1

The strengths of the study are as follows:

(1) only patients from medical and surgical populations in non–intensive care units were included, thus avoiding many of the complexities and confounding factors associated with more severe patients; and

(2) very few patients received other known nephrotoxins, making the association of renal toxicity to the antibiotics under study somewhat more likely….

abstract

https://journals.lww.com/infectdis/Fulltext/2018/01000/A_Comparison_of_Nephrotoxicity_in_Non_Intensive.1.aspx

PDF (CLIC en ARTICLE as PDF)

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February 2, 2018 at 8:53 am


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