The microbiota and microbiome in aging: potential implications in health and age-related diseases.

February 19, 2018 at 9:11 am

J Am Geriatr Soc. April 2015 V.63 N.4 P.776-81.

Zapata HJ1, Quagliarello VJ.

Author information

1 Infectious Diseases Section, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut.

Abstract

Advances in bacterial deoxyribonucleic acid sequencing allow for characterization of the human commensal bacterial community (microbiota) and its corresponding genome (microbiome).

Surveys of healthy adults reveal that a signature composite of bacteria characterizes each unique body habitat (e.g., gut, skin, oral cavity, vagina).

A myriad of clinical changes, including a basal proinflammatory state (inflamm-aging), that directly interface with the microbiota of older adults and enhance susceptibility to disease accompany aging.

Studies in older adults demonstrate that the gut microbiota correlates with diet, location of residence (e.g., community dwelling, long-term care settings), and basal level of inflammation.

Links exist between the microbiota and a variety of clinical problems plaguing older adults, including physical frailty, Clostridium difficile colitis, vulvovaginal atrophy, colorectal carcinoma, and atherosclerotic disease.

Manipulation of the microbiota and microbiome of older adults holds promise as an innovative strategy to influence the development of comorbidities associated with aging.

PDF

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406803/pdf/nihms-644813.pdf

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Entry filed under: Bacterias, HIC no SIDA, Infecciones en seniles.

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