Archive for March, 2019

Candida auris Clinical Isolates from South Korea: Identification, Antifungal Susceptibility, and Genotyping

Journal of Clinical Microbioliology March 2019 57:e01624-18

Yong Jun Kwon, Jong Hee Shin, Seung A Byun, Min Ji Choi, Eun Jeong Won, Dain Lee, Seung Yeob Lee, Sejong Chun, Jun Hyung Lee, Hyun Jung Choi, Seung Jung Kee, Soo Hyun Kim and Myung Geun Shin

Candida auris is an emerging worldwide fungal pathogen. Over the past 20 years, 61 patient isolates of C. auris (4 blood and 57 ear) have been obtained from 13 hospitals in Korea.

abstract

https://jcm.asm.org/content/57/4/e01624-18.abstract?etoc

PDF

https://jcm.asm.org/content/jcm/57/4/e01624-18.full.pdf

 

March 31, 2019 at 6:54 pm

Executive summary: Diagnosis and Management of Prosthetic Joint Infection: clinical practice Guidelines by the Infectious Diseases Society of America (IDSA).

Clinical Infectious Diseases January 2013 V.56 N.1 P.1-10   doi: 10.1093/cid/cis966.

Osmon DR, Berbari EF, Berendt AR, et al.

These guidelines are intended for use by infectious disease specialists, orthopedists, and other healthcare professionals who care for patients with prosthetic joint infection (PJI). They include evidence-based and opinion-based recommendations for the diagnosis and management of patients with PJI treated with debridement and retention of the prosthesis, resection arthroplasty with or without subsequent staged reimplantation, 1-stage reimplantation, and amputation.

FULL TEXT

https://academic.oup.com/cid/article/56/1/1/419472

PDF (HACER CLIC en PDF)

 

Clinical Infectious Diseases January 2013 V.6 N.1 P.e1-e25   doi: 10.1093/cid/cis803.

Diagnosis and Management of Prosthetic Joint Infection: clinical practice Guidelines by the Infectious Diseases Society of America (IDSA).

Osmon DR, Berbari EF, Berendt AR, et al.

These guidelines are intended for use by infectious disease specialists, orthopedists, and other healthcare professionals who care for patients with prosthetic joint infection (PJI). They include evidence-based and opinion-based recommendations for the diagnosis and management of patients with PJI treated with debridement and retention of the prosthesis, resection arthroplasty with or without subsequent staged reimplantation, 1-stage reimplantation, and amputation.

FULL TEXT

https://academic.oup.com/cid/article/56/1/e1/415705

PDF (HACER CLIC en PDF)

March 30, 2019 at 5:17 pm

BHIVA-BASHH Guidelines on the use of HIV pre-exposure prophylaxis (PrEP) 2018. 79 pag.

HIV Med. Marcj 2019 V.20  Suppl 2  P. s2-s80

FULL TEXT

https://onlinelibrary.wiley.com/doi/full/10.1111/hiv.12718

PDF

https://onlinelibrary.wiley.com/doi/epdf/10.1111/hiv.12718

March 28, 2019 at 3:34 pm

The association of surgical drains with surgical site infections – A prospective observational study

Am J Surg 2019 V.217 N.1  P.17-23

Mujagic E, Zeindler J, Coslovsky M, Hoffmann H y col

Highlights

  • The odds of SSI are significantly increased with surgical drains in general surgery.
  • This association is weaker in vascular and absent in orthopedic trauma surgery.
  • The association of drains with SSI depended on duration of surgery and wound class.
  • Duration, number, type and location of drains were associated with SSI risk.

Background

Surgical drains are widely used despite limited evidence in their favor. This study describes the associations between drains and surgical site infections (SSI).

Methods

This prospective observational double center study was performed in Switzerland between February 2013 and August 2015.

Results

The odds of SSI in the presence of drains were increased in general (OR 2.41, 95%CI 1.32–4.30, p = 0.004), but less in vascular and not in orthopedic trauma surgery. In addition to the surgical division, the association between drains and SSI depended significantly on the duration of surgery (p = 0.01) and wound class (p = 0.034). Furthermore, the duration of drainage (OR 1.24, 95%CI 1.15–1.35, p < 0.001), the number (OR 1.74, 95%CI 1.09–2.74, p = 0.019) and type of drains (open versus closed: OR 3.68, 95%CI 1.88, 6.89, p < 0.001) as well as their location (overall p = 0.002) were significantly associated with SSI.

Conclusions

The general use of drains is discouraged. However, drains may be beneficial in specific surgical procedures.

FULL TEXT

https://www.americanjournalofsurgery.com/article/S0002-9610(18)30672-X/fulltext

PDF

https://www.americanjournalofsurgery.com/article/S0002-9610(18)30672-X/pdf

March 27, 2019 at 8:04 am

Disminución del nivel de conciencia, fiebre y disnea en una paciente infectada con HIV.

Revista Argentina de Microbiologia 2014 V.46 N.3 P.271-272

Carta al Editor

Shock séptico con meningitis debido a la bacteriemia por Klebsiella pneumoniae y falla multiorgánica en el contexto de un síndrome de hiperinfección por Strongyloides stercoralis,

PDF

https://www.redalyc.org/pdf/2130/213032482015.pdf

March 24, 2019 at 5:31 pm

Infección por Strongyloides stercoralis: estudio epidemiológico, clínico, diagnóstico y terapéutico en 30 pacientes

Revista Chilena de Infectologia Junio 2011 V.28 N.3

Marcelo Corti, María F. Villafañe, Norberto Trione, Daniel Risso, Juan Carlos Abuín y Omar Palmieri

Hospital de Enfermedades Infecciosas Francisco J. Muñiz, Buenos Aires, Argentina

Antecedentes

Strongyloides stercoralis, parásito endémico de áreas tropicales y subtropicales del planeta, en sujetos inmunodeprimidos puede cursar con formas graves y aun mortales como el síndrome de hiperinfestación y la enfermedad diseminada.

Métodos

Análisis retrospectivo de las características epidemiológicas, manifestaciones clínicas, co-infección por virus de inmunodeficiencia humana (VIH), hallazgos microbiológicos y evolución de 30 pacientes con estrongiloidiasis, atendidos en el Hospital de Enfermedades Infecciosas F. J. Muñiz de Buenos Aires, entre enero 2004 y diciembre 2008.

Resultados

Se incluyeron en la evaluación 20 hombres y 10 mujeres con una mediana de edad de 33 años. Co-infección por VIH hubo en 21 pacientes (70%); la mediana de linfocitos T CD4+ en ellos al momento del diagnóstico de la parasitosis fue de 50 céls/mm3 (rango 7 a 355), (media de 56 céls/mm3). En los pacientes seronegativos para VIH, se comprobaron las siguientes co-morbilidades: tuberculosis (n: 3) y un caso de cada una de las siguientes afecciones: alcoholismo crónico, diabetes mellitus, reacción lepromatosa bajo corticotera-pia, y psoriasis en tratamiento inmunosupresor. Hubo dos pacientes sin aparentes enfermedades de base. Diecisiete pacientes presentaron enfermedad intestinal crónica con diarrea (57%), era asintomática y fue sospechada por la eosinofilia periférica (n: 7, 23%) y se clasificó como síndrome de hiperinfestación (n: 6, 20%) diagnosticado por la identificación de larvas en la materia fecal y secreciones broncopulmonares. Diecisiete pacientes (57%) presentaron eosinofilia periférica. El diagnóstico se efectuó por la visualización directa de las larvas en muestras de heces en fresco mediante la técnica de concentración de Baer-man (n: 20); por el examen copro-parasitológico seriado (n: 2) y por ambos métodos (n: 1); en líquido duodenal y materia fecal (n: 1) y por la identificación de larvas en materia fecal y secreciones respiratorias (n: 6). Letalidad global: 20% (6/30). Los pacientes con eosinofilia tuvieron una menor letalidad que aquellos sin esta respuesta (p < 0,001). No hubo correlación estadística entre la edad y la supervivencia. Sí fue significativa la correlación entre el recuento de CD4 y la letalidad, incluyendo 18 de los 21 pacientes seropositivos para VIH (p: 0,03). Finalmente, la correlación seropositividad para VIH y letalidad también fue significativa. Veintidós pacientes respondieron a la terapia antiparasitaria con ivermectina y evolucionaron favorablemente.

PDF

https://scielo.conicyt.cl/pdf/rci/v28n3/art03.pdf

March 24, 2019 at 5:28 pm

Intermediately Resistant to Penicillin and Causing Invasive Disease in South Africa in 2001 to 2005

JOURNAL OF CLINICAL MICROBIOLOGY, Oct. 2008 V.46 N.10 P.3208–3214

ia meningitidNeisseria meningitidis strains (meningococci) with decreased susceptibility to penicillin (MICs, >0.06 g/ml) have been reported in several parts of the world, but the prevalence of such isolates in Africa is poorly described. Data from an active national laboratory-based surveillance program from January 2001 through December 2005 were analyzed. A total of 1,897 cases of invasive meningococcal disease were reported, with an average annual incidence of 0.83/100,000 population. Of these cases, 1,381 (73%) had viable isolates available for further testing; 87 (6%) of these isolates tested intermediately resistant to penicillin (Peni).

Peni meningococcal isolates were distributed throughout all provinces and age groups, and there was no association with outcome or human immunodeficiency virus infection. The prevalence of Peni was lower in serogroup A (7/295; 2%) than in serogroup B (24/314; 8%), serogroup C (9/117; 8%), serogroup Y (22/248; 9%), or serogroup W135 (25/396; 6%) (P  0.02). Pulsed-field gel electrophoresis grouped 63/82 Peni isolates into nine clusters, mostly according to serogroup. The clustering of patterns from Peni isolates was not different from that of penicillinsusceptible isolates. Twelve sequence types were identified among 18 isolates arbitrarily selected for multilocus sequence typing. DNA sequence analysis of the penA gene identified 26 different alleles among the Peni isolates.

Intermediate penicillin resistance is thus widespread among meningococcal serogroups, has been selected in a variety of lineages, and, to date, does not appear to be associated with increased mortality. This is the first report describing the prevalence and molecular epidemiology of Peni meningococcal isolates from sub-Saharan Africa.

PDF

https://jcm.asm.org/content/jcm/46/10/3208.full.pdf

 

March 24, 2019 at 12:14 pm

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