Intrathecal and intraventricular antibiotics for postoperative Gram-negative meningitis and ventriculitis.

April 1, 2019 at 6:32 pm

Surg Neurol Int. september 2017 V.8 P.226.

Khan SA1, Waqas M2, Siddiqui UT2, Shamim MS2, Nathani KR2, Jooma R2, Mehmood F3.

Abstract

BACKGROUND:

Postoperative meningitis is a growing cause of concern, especially with the evolution of multidrug-resistant organism. The authors evaluate the use of intraventricular/intrathecal (IVT/IT) antibiotics for postoperative gram-negative meningitis in patients whom intravenous antibiotics were ineffective.

METHODS:

Medical records were retrospectively reviewed and neurosurgery patients with gram-negative postoperative infection meningitis/ventriculitis were enrolled in the study. Their demographics, hospital course, and outcomes were recorded in a pro forma and analyzed using Statistical Package for the Social Sciences, version 19.

RESULTS:

The review identified 21 patients with postneurosurgical gram-negative meningitis/ventriculitis who were treated with IVT or IT antibiotics. The most common organism was Acinetobacter species (n = 14; 66%). Amikacin was used in 7 patients, polymyxin B in 9 patients, and colistin in 5 patients. A combination of antibiotics was used in one patient. Cerebrospinal fluid sterility was achieved in all patients with no incidence of relapse. There was a single death, though that was not related to the infectious process as the patient had a massive pulmonary embolism.

CONCLUSION:

The findings of this study suggest that IVT and IT antibiotic therapy is a useful option in patients who are nonresponsive to standard intravenous therapy with little or no side effects.

FULL TEXT

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629845/

Advertisements

Entry filed under: Antimicrobianos, Bacterias, Bacteriemias, Biología Molecular, Epidemiología, FIEBRE en el POSTOPERATORIO, Health Care-Associated Infections, Infecciones del SNC, Infecciones nosocomiales, Infecciones sitio quirurgico, Metodos diagnosticos, REPORTS, Resistencia bacteriana, Sepsis, Update.

Candida auris Clinical Isolates from South Korea: Identification, Antifungal Susceptibility, and Genotyping Management of post-neurosurgical meningitis: narrative review.


Calendar

April 2019
M T W T F S S
« Mar   May »
1234567
891011121314
15161718192021
22232425262728
2930  

Most Recent Posts


%d bloggers like this: