Archive for January 29, 2020

PERSPECTIVE – A Novel Coronavirus Emerging in China — Key Questions for Impact Assessment

New England J of Medicine January 24, 2020

V.J. Munster and Others

novel coronavirus, designated as 2019-nCoV, emerged in Wuhan, China, at the end of 2019. As of January 24, 2020, at least 830 cases had been diagnosed in nine countries: China, Thailand, Japan, South Korea, Singapore, Vietnam, Taiwan, Nepal, and the United States. Twenty-six fatalities occurred, mainly in patients who had serious underlying illness.1 Although many details of the emergence of this virus — such as its origin and its ability to spread among humans — remain unknown, an increasing number of cases appear to have resulted from human-to-human transmission. Given the severe acute respiratory syndrome coronavirus (SARS-CoV) outbreak in 2002 and the Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in 2012 …

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https://www.nejm.org/doi/full/10.1056/NEJMp2000929?query=RP

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https://www.nejm.org/doi/pdf/10.1056/NEJMp2000929?articleTools=true

January 29, 2020 at 8:30 am

Brief Report – A Novel Coronavirus from Patients with Pneumonia in China, 2019

New England J of Medicine January 24, 2020

Zhu and Others

In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.)

FULL TEXT

https://www.nejm.org/doi/full/10.1056/NEJMoa2001017?query=RP

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https://www.nejm.org/doi/pdf/10.1056/NEJMoa2001017?articleTools=true

January 29, 2020 at 8:29 am

EDITORIAL – Another Decade, Another Coronavirus

New England J of Medicine January 24, 2020

Perlman

For the third time in as many decades, a zoonotic coronavirus has crossed species to infect human populations. This virus, provisionally called 2019-nCoV, was first identified in Wuhan, China, in persons exposed to a seafood or wet market. The rapid response of the Chinese public health, clinical, and scientific communities facilitated recognition of the clinical disease and initial understanding of the epidemiology of the infection. First reports indicated that human-to-human transmission was limited or nonexistent, but we now know that such transmission occurs, although to what extent remains unknown. Like outbreaks caused by two other pathogenic human respiratory coronaviruses (severe acute respiratory syndrome coronavirus [SARS-CoV] and Middle East respiratory syndrome coronavirus [MERS-CoV]), 2019-nCoV causes respiratory disease that is often severe.1 As of January 24, 2020, there were more than 800 reported cases, with a mortality rate of 3% (https://promedmail.org/. opens in new tab) …

FULL TEXT

https://www.nejm.org/doi/full/10.1056/NEJMe2001126?query=RP

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https://www.nejm.org/doi/pdf/10.1056/NEJMe2001126?articleTools=true

January 29, 2020 at 8:28 am


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