Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China.

March 23, 2020 at 11:57 am

Clin Infect Dis. March 16, 2020 

Wang Z1, Yang B2, Li Q1, Wen L1, Zhang R1.

Abstract

BACKGROUND:

From December 2019 to February 2020, 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a serious outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China. Related clinical features are needed.

METHODS:

We reviewed 69 patients who were hospitalized in Union hospital in Wuhan between January 16 to January 29, 2020. All patients were confirmed to be infected with SARS-CoV-2 and the final date of follow-up was February 4, 2020.

RESULTS:

The median age of 69 enrolled patients was 42.0 years (IQR 35.0-62.0), and 32 patients (46%) were men. The most common symptoms were:

fever (60[87%]),

cough (38[55%]), and

fatigue (29[42%]).

Most patients received antiviral therapy (66 [98.5%] of 67 patients) and antibiotic therapy (66 [98.5%] of 67 patients).

As of February 4, 2020, 18 (26.9%) of 67 patients had been discharged, and five patients had died, with a mortality rate of 7.5%.

According to the lowest SpO2 during admission, cases were divided into the SpO2 ≥ 90% group (n=55) and the SpO2 < 90% group (n=14).

All 5 deaths occurred in the SpO2 < 90% group. Compared with SpO2 ≥ 90% group, patients of the SpO2 < 90% group were older, and showed more comorbidities and higher plasma levels of IL6, IL10, lactate dehydrogenase, and c reactive protein.

Arbidol treatment showed tendency to improve the discharging rate and decrease the mortality rate.

CONCLUSIONS:

COVID-19 appears to show frequent fever, dry cough, and increase of inflammatory cytokines, and induced a mortality rate of 7.5%. Older patients or those with underlying comorbidities are at higher risk of death.

FULL TEXT

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa272/5807944

PDF (CLIC en DOWNLOAD PDF)

Entry filed under: Biología Molecular, Epidemiología, FIEBRE en el POST-VIAJE, Infecciones emergentes, Infecciones respiratorias, Infecciones virales, Medicina del viajero, Metodos diagnosticos, Prevencion y Control de Infecciones, REPORTS, Sepsis, Update.

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