REVIEW ARTICLE – PCT to Distinguish Viral From Bacterial Pneumonia – Systematic Review and Meta-analysis 

March 24, 2020 at 8:47 pm

Clin Infect Dis, 1 February 2020, V.70 N.3, P.538–542

Because of the diverse etiologies of community-acquired pneumonia (CAP) and the limitations of current diagnostic modalities, serum procalcitonin levels have been proposed as a novel tool to guide antibiotic therapy. Outcome data from procalcitonin-guided therapy trials have shown similar mortality, but the essential question is whether the sensitivity and specificity of procalcitonin levels enable the practitioner to distinguish bacterial pneumonia, which requires antibiotic therapy, from viral pneumonia, which does not. In this meta-analysis of 12 studies in 2408 patients with CAP that included etiologic diagnoses and sufficient data to enable analysis, the sensitivity and specificity of serum procalcitonin were 0.55 (95% confidence interval [CI], .37–.71; I2 = 95.5%) and 0.76 (95% CI, .62–.86; I2 = 94.1%), respectively. Thus, a procalcitonin level is unlikely to provide reliable evidence either to mandate administration of antibiotics or to enable withholding such treatment in patients with CAP.

FULL TEXT

https://academic.oup.com/cid/article/70/3/538/5523199

PDF (CLIC en PDF)

Entry filed under: Bacterias, Biología Molecular, BIOMARCADORES, Epidemiología, Infecciones respiratorias, Infecciones virales, Influenza, Inmunizaciones, Meta-Análisis, Metodos diagnosticos, REPORTS, REVIEWS, Sepsis, Update.

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