COVID-19 Illness in Native and Immunosuppressed States – A Clinical-Therapeutic Staging Proposal

March 29, 2020 at 10:58 am

Journal of Heart and Lung Transplantation March 2020

Hasan K. Siddiqi MD, MSCR , Mandeep R. Mehra MD, MSc

The onslaught of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated coronavirus disease 2019 (COVID-19) has gripped the world in a pandemic and challenged the culture, economy and healthcare infrastructure of its population. It has become increasingly important that health systems and their clinicians adopt a universal consolidated framework to recognize the staged progression of COVID-19 illness in order to deploy and investigate targeted therapy likely to save lives. The largest report of COVID-19 from the Chinese Centers for Disease Control and Prevention summarized findings from 72, 314 cases and noted that while 81% were of a mild nature with an overall case fatality rate of 2.3%, a small sub-group of 5% presented with respiratory failure, septic shock and multi-organ dysfunction resulting in fatality in half of such cases, a finding that suggests that it is within this group that the opportunity for life saving measures may be most pertinent….

FULL TEXT

https://www.jhltonline.org/article/S1053-2498(20)31473-X/fulltext?mobileUi=0

PDF

https://www.jhltonline.org/article/S1053-2498(20)31473-X/pdf

 

Entry filed under: Biología Molecular, Desinfection and Sterilization, Epidemiología, FIEBRE en el POST-VIAJE, Health Care-Associated Infections, HIC no SIDA, Infecciones emergentes, Infecciones respiratorias, Infecciones virales, Medicina del viajero, Metodos diagnosticos, Prevencion y Control de Infecciones, REPORTS, Sepsis, Update.

Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents Jerarquización de la Evidencia. Niveles de Evidencia y Grados de Recomendación de uso actual


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