Posts filed under ‘Infecciones de transmision sexual’

Worsening Epidemic of HIV and Syphilis Among Men Who Have Sex With Men in Jiangsu Province, China

Clinical Infectious Diseases June 15, 2014 V.58 N.12 P.1753-1759

Hai-Tao Yang1,a, Weiming Tang2,a, Zhan-Pei Xiao3, Ning Jiang4, Tanmay Mahapatra2, Xi-Ping Huan1, Yue-Ping Yin4, Xiao-Liang Wang1, Xiang-Sheng Chen4, and Geng-Feng Fu1

1Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, Jiangsu, China

2Department of Epidemiology, School of Public Health, University of California, Los Angeles

3Henan Provincial Center for Disease Prevention and Control, Zhengzhou, Henan

4National Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing, Jiangsu, China

Correspondence: Geng-Feng Fu, PhD, Jiangsu Provincial Center for Disease Prevention and Control, A502, 172 Jiangsu Road, Gulou District, Nanjing, Jiangsu 210009, China (


Epidemics of human immunodeficiency virus (HIV) and syphilis among men who have sex with men (MSM) are major public health concerns in most parts of China. A dearth of information regarding the current trend of HIV in this hard-to-reach population in several regions including Jiangsu, coupled with the reemergence of syphilis, calls for an effort to understand the dynamics of the dual epidemic in this province.


To estimate the occurrence and burden of these 2 sexually transmitted diseases and the distribution of their potential sociobehavioral correlates among MSM in Jiangsu, 2 cohort studies were conducted in Yangzhou and Changzhou cities.


Among 839 participants, 48% were married, 51.7% had sex with women in the last 6 months, and 25.5% did not use condoms during their last anal intercourse. The observed incidence of HIV was 13.59 and 12.62 and that of syphilis was 7.33 and 13.25 per 100 person-years among the participants of Yangzhou and Changzhou, respectively. The baseline prevalence of HIV and syphilis was 16.0% and 29.9% in Yangzhou and 13.6% and 14.9% in Changzhou, respectively.


Considerably high incidence and prevalence of HIV and syphilis among participants and their potential bridging role in transmitting these infections to the general population in Yangzhou and Changzhou cities calls for urgent effective intervention strategies.




EDITORIAL Commentary

The Next Tsunami? HIV Spread in Asian Men Who Have Sex With Men

Kenneth H. Mayer

Harvard Medical School, Beth Israel Deaconess Medical Center, and The Fenway Institute, Fenway Health, Boston, Massachusetts

Correspondence: Kenneth Mayer, MD, The Fenway Institute, 1340 Boylston Street, Boston, MA 02215 (

Over the past few years, human immunodeficiency virus (HIV) incidence has appreciably decreased in several countries [1]. However, in many parts of the world, HIV is spreading increasing rapidly among men who have sex with men (MSM) [2]. This trend of the epidemic becoming increasingly concentrated among MSM has been particularly marked in several urban epicenters throughout Asia in recent years, and in the current issue of Clinical Infectious Diseases, Yang et al describe a worsening epidemic of HIV and syphilis among MSM in 2 cities in Jiangsu Province in eastern China [3] . The authors found that HIV prevalence initially ranged between 13.6% and 16%, with syphilis prevalence ranging between 14.9% and 29.9%, but subsequent annualized HIV incidence was >12.5%. These rates are extremely high, and portend a worsening HIV/AIDS epidemic among Chinese MSM. Similar findings have been noted in several other recent studies from China [4–9] and nearby countries [10, 11], and contribute to a growing worrisome body of literature suggesting that AIDS in Asia is disproportionately becoming an MSM epidemic. The rapid spread of HIV among Asian MSM is particularly concerning because the majority of the world’s population lives in Asia, with an increasing number of individuals living in urban epicenters. Some MSM have female, as well as male partners, and/or inject drugs, so transmission outside their core group is highly likely. The potential for amplified transmission in these densely …



June 9, 2014 at 9:24 am

Sexually transmitted infections – Controversies and conundrums in screening, treatment and stigma

Current Opinion in Infect. Dis  Feb 2014  V.27  N.1 P.53–55

Rogstad, Karen

Sheffield Teaching Hospitals NHS Foundation Trust and Undergraduate Dean, University of Sheffield Medical School, Sheffield, UK

Correspondence to Karen Rogstad, Consultant in HIV and Sexual Health, Sheffield Teaching Hospitals, NHS Foundation Trust and Undergraduate Dean, University of Sheffield School of Medicine, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK. Tel: +44 114 271 1900; e-mail:

The five review topics in this issue highlight some of the key controversies in sexually transmitted infections (STIs), and their control.

The authors are from all corners of the world and work in different healthcare systems, but all have an awareness of the internationality of STIs, which do not conform to national boundaries.

A problem in one country can rapidly spread to other continents, requiring a world view of STI treatment and control, and international collaboration and support.

There are some major areas of concern: in men who have sex with men (MSM), there is a resurgent syphilis epidemic, hepatitis C in HIV-positive men has an annual incidence of transmission of 2–4% [1], and there is no decrease in HIV incidence in MSM; gonorrhoea has increased globally by 21% over 3 years [2] and multidrug, extensively drug-resistant and potentially untreatable




June 5, 2014 at 8:39 am

Primary and Secondary Syphilis — United States, 2005–2013

MMWR My 9, 2014 V.63 N.18 P.402-406

Monica E. Patton, MD1, John R. Su, MD2, Robert Nelson, MPH2, Hillard Weinstock, MD2

1EIS officer, CDC; 2Division of Sexually Transmitted Disease Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC (Corresponding author: Monica Patton,, 404-718-8648) 

In 2013, based on data reported as of April 28, 2014, the rate of reported primary and secondary syphilis in the United States was 5.3 cases per 100,000 population, more than double the lowest-ever rate of 2.1 in 2000.

To characterize the recent epidemiology of syphilis in the United States, CDC analyzed data from the National Notifiable Diseases Surveillance System (NNDSS) for cases of primary and secondary syphilis diagnosed during 2005–2013 with a focus on states that reported the sex of sex partners during 2009–2012 to describe reported syphilis among gay, bisexual, and other men who have sex with men (collectively referred to as MSM).

During 2005–2013, primary and secondary syphilis rates increased among men of all ages and races/ethnicities across all regions of the United States.

Recent years have shown an accelerated increase in the number of cases, with the largest increases occurring among MSM. Among women, rates increased during 2005–2008 and decreased during 2009–2013, with different trends among different racial/ethnic groups.

Racial/ethnic disparities in reported syphilis persisted during 2005–2013, likely reflecting social determinants of health, such as socioeconomic status, that might contribute to the burden of syphilis in a community (1).

These findings underscore the need for continued syphilis prevention measures among MSM….


PDF (see p.402)

June 4, 2014 at 3:11 pm

Ciprofloxacin Resistance and Gonorrhea Incidence Rates in 17 Cities, United States, 1991–2006

Emerging Infectious Diseases April 2014 V.20 N.4

Harrell W. ChessonComments to Author , Robert D. Kirkcaldy, Thomas L. Gift, Kwame Owusu-Edusei, and Hillard S. Weinstock

Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Antimicrobial drug resistance can hinder gonorrhea prevention and control efforts.

In this study, we analyzed historical ciprofloxacin resistance data and gonorrhea incidence data to examine the possible effect of antimicrobial drug resistance on gonorrhea incidence at the population level.

We analyzed data from the Gonococcal Isolate Surveillance Project and city-level gonorrhea incidence rates from surveillance data for 17 cities during 1991–2006.

We found a strong positive association between ciprofloxacin resistance and gonorrhea incidence rates at the city level during this period. Their association was consistent with predictions of mathematical models in which resistance to treatment can increase gonorrhea incidence rates through factors such as increased duration of infection.

These findings highlight the possibility of future increases in gonorrhea incidence caused by emerging cephalosporin resistance.


March 29, 2014 at 11:11 am

Practice guidelines for the diagnosis and management of skin and soft-tissue infections.

Clin Infect Dis 2005 Nov 15; 41(10) :1373-406.


Stevens DL, Bisno AL, Chambers HF, et al.

Infectious Diseases Section, Veterans Affairs Medical Center, Boise, Idaho 83702, USA.

Soft-tissue infections are common, generally of mild to modest severity, and are easily treated with a variety of agents. An etiologic diagnosis of simple cellulitis is frequently difficult and generally unnecessary for patients with mild signs and symptoms of illness. Clinical assessment of the severity of infection is crucial, and several classification schemes and algorithms have been proposed to guide the clinician [1]. However, most clinical assessments have been developed from either retrospective studies or from an author’s own “clinical experience,” illustrating the need for prospective studies with defined measurements of severity coupled to management issues and outcomes….



Stevens et al. (2005; 41:1373–1406)

In a guideline published in the 15 November 2005 issue of the journal (Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the management of skin and soft-tissue infections. Clin Infect Dis 2005; 41:1373–1406), an error appeared in the first sentence of the Note Added in Proof, which stated that dalbavancin had been …


March 10, 2014 at 8:52 pm

Chlamydia and male lower urinary tract diseases.

Korean J Urol. 2013 Feb;54(2):73-7.

Lee YS, Lee KS.

Department of Urology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.


Of the chlamydia species that can cause infections in humans, C. trachomatis is responsible for lower urinary tract diseases in men and women. C. trachomatis infections are prevalent worldwide, but current research is focused on females, with the burden of disease and infertility sequelae considered to be a predominantly female problem.

However, a role for this pathogen in the development of male urethritis, epididymitis, and orchitis is widely accepted. Also, it can cause complications such as chronic prostatitis and infertility.

This review summarizes C. trachomatis infection in the male genitourinary tract, including urethritis, epididymitis, orchitis, and its complications, and addresses the microbiology, epidemiology, screening, clinical manifestations, diagnosis, and treatment.


February 20, 2014 at 12:43 pm

How can the treatment of bacterial vaginosis be improved to reduce the risk of preterm delivery?

Womens Health (Lond Engl). 2012 Sep;8(5):491-3.

Menard JP, Bretelle F.


November 30, 2013 at 2:18 pm

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