Posts filed under ‘Infecciones parasitarias’

Abordaje terapéutico actual de la malaria grave importada

Revista Española de Quimioterapia Septiembre 2016 V.29 Supl.1




Resistencia a los antimaláricos




April 9, 2017 at 12:44 pm

A New Development in Trypanosoma cruzi Detection

Journal of Clinical Microbiology March 2017 V.55 N.3 P.690-692

Herbert B. Tanowitz and Louis M. Weiss

Department of Pathology, Division of Tropical Medicine and Parasitology, and Department of Medicine, Division of Infectious Disease, Albert Einstein College of Medicine, Bronx, New York, USA

Chagas disease is caused by the parasite Trypanosoma cruzi and is an important cause of morbidity and mortality in areas of Latin America where Chagas disease is endemic and among infected individuals who have migrated to nonendemic areas of North America and Europe.

There are many diagnostic tests that are employed in the serological diagnosis of this infection. In this issue of the Journal of Clinical Microbiology, Bautista-López et al. provide characterization of excretory vesicles (EVs) from Vero cells infected with T. cruzi and provide data on the EVs produced by trypomastigotes and amastigotes (N. L. Bautista-López et al., J Clin Microbiol 55:744–758, 2017,

Their proteomic study defines potential targets to evaluate for improved diagnostic tests, effects on host cell biology that contribute to the pathogenesis of infection, and vaccine candidates. If any of the EV-associated proteins identified were to be correlated to cure of infection, this would be a major advance….


February 24, 2017 at 8:01 am

Amibas de vida libre en seres humanos

Mónica Liliana Peralta Rodríguez1, Jaime de Jesús Ayala Oviedo1

1 Docentes del área de Morfofisiología. Facultad de Medicina, Universidad de la Sabana, Bogotá (Colombia).

Entre las enfermedades graves, peligrosas y de gran importancia epidemiológica se encuentran la meningitis y la encefalitis, que pueden llevar a invalidez o muerte. Los agentes etiológicos que las producen generalmente son bacterias, virus y hongos. En cuanto a los protozoos causantes de meningitis y encefalitis, se encuentran las amibas de vida libre. Los individuos infectados con estas amibas tienen como antecedente el haber tenido contacto con aguas contaminadas en días recientes, especialmente de piscinas o aguas termales. Naegleria fowleri parasita a individuos aparentemente saludables, niños o óvenes y es la causante de meningoencefalitis amebiana primaria, que se caracteriza por su rápida evolución y luego la muerte. Algunas especies del género Acanthamoeba, Balamuthia mandrillaris, y recientemente Sappinia pedata, producen encefalitis amebiana granulomatosa, que se presenta de forma subaguda o crónica; generalmente parasitan a individuos inmunosuprimidos. Además, ciertas especies de Acanthamoeba producen queratitis, que se confunden con las producidas por Herpes simplex u hongos. Estas amibas también causan infecciones severas en pulmones, oídos, piel y nariz. El diagnóstico de estas amibas en la mayoría de los casos se hace después de la muerte de los individuos infectados. En cuanto a su tratamiento, se han empleado combinaciones de varios antimicrobianos con resultados poco alentadores. Estas amibas no son lo suficientemente conocidas por el personal de salud, por lo tanto, en esta revisión se pretende evidenciar los aspectos más relevantes de éstas, ya que puede haber subdiagnóstico o confusión con otros agentes etiológicos y no sospechar de la presencia de amibas de vida libre.


February 13, 2017 at 8:50 am

The dangerous turn of “brain eating amoeba” in Sindh, Pakistan.

J Infect Public Health. 2015 May-Jun;8(3):305-6. doi: 10.1016/j.jiph.2014.10.003. Epub 2014 Nov 27.

Letter to Editor

Ul Islam MY1, Rahim SA2, Salim A2.

Author information

1Dow Medical College, DUHS, Karachi, Pakistan. Electronic address:

2Dow Medical College, DUHS, Karachi, Pakistan


February 13, 2017 at 8:49 am

Primary amoebic meningoencephalitis caused by Naegleria fowleri: an old enemy presenting new challenges.

PLoS Negl Trop Dis. 2014 Aug 14;8(8):e3017. doi: 10.1371/journal.pntd.0003017. eCollection 2014.

Siddiqui R1, Khan NA1.

Author information

1Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.


First discovered in 1899, Naegleria fowleri is a protist pathogen, known to infect the central nervous system and produce primary amoebic meningoencephalitis. The most distressing aspect is that the fatality rate has remained more than 95%, despite our advances in antimicrobial chemotherapy and supportive care. Although rare worldwide, most cases have been reported in the United States, Australia, and Europe (France). A large number of cases in developing countries go unnoticed. In particular, religious, recreational, and cultural practices such as ritual ablution and/or purifications, Ayurveda, and the use of neti pots for nasal irrigation can contribute to this devastating infection. With increasing water scarcity and public reliance on water storage, here we debate the need for increased awareness of primary amoebic meningoencephalitis and the associated risk factors, particularly in developing countries


February 13, 2017 at 8:47 am

Improved Method for the Detection and Quantification of Naegleria fowleri in Water and Sediment Using Immunomagnetic Separation and Real-Time PCR.

J Parasitol Res. 2013;2013:608367. doi: 10.1155/2013/608367. Epub 2013 Oct 21.

Mull BJ1, Narayanan J, Hill VR.

Author information

1Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, 1600 Clifton Road, NE, Mail Stop D-66, Atlanta, GA 30329-4018, USA.


Primary amebic meningoencephalitis (PAM) is a rare and typically fatal infection caused by the thermophilic free-living ameba, Naegleria fowleri. In 2010, the first confirmed case of PAM acquired in Minnesota highlighted the need for improved detection and quantification methods in order to study the changing ecology of N. fowleri and to evaluate potential risk factors for increased exposure. An immunomagnetic separation (IMS) procedure and real-time PCR TaqMan assay were developed to recover and quantify N. fowleri in water and sediment samples. When one liter of lake water was seeded with N. fowleri strain CDC:V212, the method had an average recovery of 46% and detection limit of 14 amebas per liter of water. The method was then applied to sediment and water samples with unknown N. fowleri concentrations, resulting in positive direct detections by real-time PCR in 3 out of 16 samples and confirmation of N. fowleri culture in 6 of 16 samples. This study has resulted in a new method for detection and quantification of N. fowleri in water and sediment that should be a useful tool to facilitate studies of the physical, chemical, and biological factors associated with the presence and dynamics of N. fowleri in environmental systems.


February 13, 2017 at 8:45 am

Naeglaeria infection of the central nervous system, CT scan findings: a case series.

J Pak Med Assoc. 2013 Mar;63(3):399-402.

Naqi R1, Azeemuddin M.

Author information

1Department of Radiology, Dow University of Health Sciences, 2Department of Radiology, Aga Khan University Hospital, Karachi.


The imaging findings in four cases of a rare infection of the central nervous system caused by amoebae, Naeglaeria fowleri are presented. Naeglaeria fowleri are pathogenic free-living amoebae. They cause primary amoebic meningoencephalitis (PAM), a rapidly fatal disease of the central nervous system. The computed tomography brain findings in 3 (75%) of our cases of pan amoebic meningoencephalitis showed non-specific brain oedema; 2 (66%) of these cases also had moderate hydrocephalus and among that 1 (50%) case showed an old lacunar infarction in peri-ventricular region. In the remaining 1 (25%) case the scan was normal with no evidence of oedema or abnormal lesion. Out of three cases with diffuse brain oedema, postcontrast images showed abnormal meningeal enhancement throughout the brain parenchyma in 1 (33%) case. However, no definite focal enhancing lesion was noted. In the rest of the cases, no abnormal parenchymal or meningeal enhancement was seen on post-contrast images.


February 13, 2017 at 8:44 am

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