Posts filed under ‘Infecciones senos paranasales y oidos’

Infectious complications in chronic lymphocytic leukemia.

Mediterr J Hematol Infect Dis. 2012;4(1):e2012070. doi: 10.4084/MJHID.2012.070. Epub 2012 Nov 5.

Nosari A1.

Author information

1Divisione di Ematologia, Niguarda Ca’ Granda Hospital, Piazza Ospedale Maggiore 3 – 20162 Milano, Italy. Tel: 39-02-64442668.


Infectious complications have been known to be a major cause of morbidity and mortality in Chronic Lymphocytic Leukemia (CLL) patients who are prone to infections because of both the humoral immunodepression inherent to the hematologic disease and to the immunosuppression related to the therapy.

The majority of infections in CLL patients treated with alkilating agents is of bacterial origin. The immunodeficiency and natural infectious history of alkylator-resistant, corticosteroid-treated patients appears to have changed with the administration of purine analogs, which has been complicated by very severe and unusual infections and also more viral infections due to sustained reduction of CD4-positive T lymphocytes.

The subsequent introduction of monoclonal antibodies in therapies, in particular alemtuzumab, further increased the immunodepression, increasing also infections which appeared more often in patients with recurrent neutropenia due to chemotherapy cycles.

Epidemiological data regarding fungal infections in lymphoproliferative disorders are scarce.

Italian SEIFEM group in a retrospective multicentre study regarding CLL patients reported an incidence of mycoses 0.5%; however, chronic lymphoproliferative disorders emerged as second haematological underlying disease after acute leukemia in a French study on aspergillosis; in particular CLL with aspergillosis accounted for a third of these chronic lymphoproliferative diseases presenting mould infection.


February 23, 2017 at 7:49 am

Enfermedades infecciosas en el paciente diabético y otros temas

La Gaceta de Infectología y Microbiología Clínica Diciembre 2007 V.1 N.2 


EDITORIAL: Azitromicina en el tratamiento de gastroenteritis bacteriana con énfasis en Shigelosis

Bacterias con alta tasa de mutación


Enfermedades infecciosas en el paciente diabético – Parte 1 Aspectos bioquímicos deñ Pie Diabético

Enfermedades infecciosas en el paciente diabético – Parte 2 Infecciones comunes

Enfermedades infecciosas en el paciente diabético – Parte 3 Etiología y Tratamiento de infecciones

Enfermedades infecciosas en el paciente diabético – Parte 4 Infecciones en el Pie Diabético

Revistas de Revistas



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October 11, 2013 at 9:23 am

Canadian guidelines for rhinosinusitis – practical tools for the busy clinician.

BMC Ear Nose Throat Disord. 2012 Feb 1;12:1.

Kilty S.


Department of Otolaryngology-Head and Neck Surgery, The Ottawa Hospital, University of Ottawa, ON, Canada.


Acute bacterial rhinosinusitis (ABRS) and chronic rhinosinusitis (CRS) frequently present in clinical practice. Guidelines for management of these conditions have been published extensively in the past. However, a set of guidelines that addressed issues specific to the Canadian environment while offering clear guidance for first-line clinicians was needed, and resulted in the recent publication of Canadian clinical practice guidelines for ABRS and CRS. In addition to addressing issues specific to Canadian physicians, the presented guidelines are applicable internationally, and offer single algorithms for the diagnosis and management of ABRS and CRS, as well as expert opinion in areas that do not have an extensive evidence base. This commentary presents major points from the guidelines, as well as the intended impact of the guidelines on clinical practice.

See guidelines at:


May 2, 2013 at 12:56 pm

MEDICINA (Buenos Aires) 2012; 72: 484-494



Sociedad Argentina de Infectología (SADI),2Sociedad Argentina de Pediatría (SAP), 3Sociedad Argentina de Medicina (SAM), 4Sociedad Argentina de Bacteriología, Micología y Parasitología Clínica (SADEBAC)

Las infecciones respiratorias altas son la primera causa de prescripción de antibióticos. La faringitis aguda es de origen viral en la mayoría de los casos; los episodios virales pueden diferenciarse de  los de origen bacteriano producidos por Streptococcus pyogenes por criterios clínico-epidemiológicos (criterios  de Centor), por pruebas diagnósticas rápidas o por el cultivo de fauces. Cuando la etiología es estreptocócica,  la droga de elección es penicilina V (cada 12 horas). La otitis media aguda (OMA) es una de las causas más  frecuentes de prescripción de antibióticos en niños. Los patógenos principales son Streptococcus pneumoniae,  Haemophilus influenzae no tipable y Moraxella catarrhalis. Los antecedentes, la evaluación clínica junto con la otoscopía permiten establecer el diagnóstico. En niños menores de 2 años se recomienda tratamiento antibiótico precoz al igual que en niños mayores de 2 años con otitis bilateral, otorrea, presencia de comorbilidad o cuadro clínico grave. En la Argentina, debido a los bajos niveles de resistencia de S. pneumoniae a penicilina la droga de elección es amoxicilina; ante falta de respuesta al tratamiento puede utilizarse amoxicilina/clavulánico para cubrir cepas de H. influenzae y de M. catarrhalis productoras de betalactamasas. Las rinosinusitis son virales en la mayoría de los casos y menos del 5% se complican con sinusitis bacteriana. El diagnóstico es clínico y en general no se requieren estudios complementarios. Los patógenos bacterianos implicados son los mismos que causan OMA, por esta razón también se recomienda la amoxicilina como droga de elección…


January 31, 2013 at 5:51 pm

Consensus guidelines for the management of upper respiratory tract infections.

Medicina (B Aires). 2012 V.72 N.6 P.484-94.     

Lopardo G, Calmaggi A, Clara L, Levy Hara G, Mykietiuk A, Pryluka D, Ruvinsky S, Vujacich C, Yahni D, Bogdanowicz E, Klein M, López Furst MJ, Pensotti C, Rial MJ, Scapellato P.


Sociedad Argentina de Infectología (SADI).


Upper respiratory tract infections are the most common source of antibiotic prescriptions. Acute pharyngitis is caused mainly by viruses, viral cases can be distinguished from acute streptococcal pharyngitis using Centor clinical epidemiological criteria, by rapid antigen tests or throat culture. Treatment of choice for streptococcal infection is penicillin V given in two daily doses. In children, acute otitis media (AOM) is the infection for which antibiotics are most often prescribed. Predominant causative pathogens include Streptococcus pneumoniae, Haemophilus influenzae non-type b and Moraxella catarrhalis. Diagnosis is based on history, physical examination and otoscopic exam. Antibiotic treatment should be initiated promptly in all children < 2 years of age, and in older children presenting bilateral AOM, otorrhoea, co-morbidities or severe illness. In Argentina, amoxicillin is the drug of choice given the low penicillin resistance rates for S. pneumoniae. In children who fail amoxicillin therapy, amoxicillin/clavulanate provides better coverage against beta-lactamase producing H. influenzae and M. catarrhalis. Rhinosinusitis is caused mainly by viruses, secondary bacterial complication occurs in less than 5% of cases. Diagnosis is based on physical examination and additional studies are not usually required. Acute bacterial sinusitis is caused by the same pathogens that cause AOM and amoxicillin is the drug of choice.


December 27, 2012 at 9:01 am

Epidemic of invasive pneumococcal disease, western Canada, 2005-2009.

Emerg Infect Dis. 2012 May  V.18 N.5  P.733-40.

Tyrrell GJ, Lovgren M, Ibrahim Q, Garg S, Chui L, Boone TJ, Mangan C, Patrick DM, Hoang L, Horsman GB, Van Caeseele P, Marrie TJ.

Provincial Laboratory for Public Health (Microbiology) Edmonton, Alberta, Canada.


In Canada before 2005, large outbreaks of pneumococcal disease, including invasive pneumococcal disease caused by serotype 5, were rare. Since then, an epidemic of serotype 5 invasive pneumococcal disease was reported: 52 cases during 2005, 393 during 2006, 457 during 2007, 104 during 2008, and 42 during in 2009. Of these 1,048 cases, 1,043 (99.5%) occurred in the western provinces of Canada. Median patient age was 41 years, and most (659 [59.3%]) patients were male. Most frequently representing serotype 5 cases (compared with a subset of persons with non-serotype 5 cases) were persons who were of First Nations heritage or homeless. Restriction fragment-length polymorphism typing indicated that the epidemic was caused by a single clone, which multilocus sequence typing identified as sequence type 289. Large pneumococcal epidemics might go unrecognized without surveillance programs to document fluctuations in serotype prevalence.


August 28, 2012 at 9:22 pm

Actinomycosis of the paranasal sinuses.

Acta Otorrinolaringol Esp. 2012 Jun 13.

Sánchez Legaza E, Cercera Oliver C, Miranda Caravallo JI.

Servicio de ORL, Hospital de Algeciras, Cádiz, España.

La actinomicosis es una enfermedad granulomatosa crónica supurada específica de tejidos blandos, producida por Actinomyces Israelii, bacteria Gram positiva anaerobia muy difícil de cultivar, y comensal saprofito de la cavidad oral (criptas amigdalares, saliva y surcos gingivodentales) y tracto gastrointestinal, que se hace patógeno ante erosiones de mucosa orofaríngea como los traumas maxilofaciales, caries dental, microtraumatismos gingivales y extracciones dentales.

Presenta varias formas anatomoclínicas: cervicofacial: (50%) de tipo ósea, localizada preferentemente a nivel submandibular o parotídeo, siendo excepcional la sinusal; y otras: abdomino-pélvica (23%), y torácico-pulmonar (17%)

Es una patología rara en la actualidad, describiéndose en los últimos 25 anos ˜ una disminución considerable de su incidencia, atribuyéndose a la mejor higiene dental, fluorización del agua, y sobre todo, al empleo generalizado de antibióticos. No suele sospecharse inicialmente, de hecho, la mayoría de los casos publicados en la literatura se diagnosticaron tras resecciones quirúrgicas, probablemente por el bajo índice de sospecha junto con las dificultades que conlleva el diagnóstico microbiológico ….



August 15, 2012 at 8:59 am

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