Posts filed under ‘Infecciones y Alimentos’

Minireview – Nipah Virus Infection

J. Clin. Microbiol. June 2018 56:10 e01875-17

Brenda S. P. Ang, Tchoyoson C. C. Lim, and Linfa Wang

Nipah virus, a paramyxovirus related to Hendra virus, first emerged in Malaysia in 1998.

Clinical presentation ranges from asymptomatic infection to fatal encephalitis.

Malaysia has had no more cases since 1999, but outbreaks continue to occur in Bangladesh and India.

In the Malaysia-Singapore outbreak, transmission occurred primarily through contact with pigs, whereas in Bangladesh and India, it is associated with ingestion of contaminated date palm sap and human-to-human transmission.

Bats are the main reservoir for this virus, which can cause disease in humans and animals.

There are currently no effective therapeutics, and supportive care and prevention are the mainstays of management.




June 12, 2018 at 7:37 am

Pre-existing medical conditions associated with Vibrio vulnificus septicaemia.

Epidemiol Infect. 2014 Apr;142(4):878-81.

Menon MP1, Yu PA1, Iwamoto M1, Painter J1.

Author information

1Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.


Vibrio vulnificus (Vv) can result in severe disease. Although pre-existing liver disease is a recognized risk factor for serious infection, the relative importance of other comorbidities has not been fully assessed.

We analysed reports of Vv infections submitted to CDC from January 1988 to September 2006 in order to assess the role of pre-existing conditions contributing to severe outcomes.

A total of 1212 patients with Vv infection were reported. Only patients with liver disease [adjusted odds ratio (aOR) 5.1)] were more likely to become septic when exposure was due to contaminated food.

Patients with liver disease (aOR 4.1), a haematological disease (aOR 3.2), or malignancy (aOR 3.2) were more likely to become septic when infection was acquired via a non-foodborne exposure.

As such, patients with these pre-existing medical conditions should be advised of the risk of life-threatening illness after eating undercooked contaminated seafood or exposing broken skin to warm seawater


February 17, 2017 at 4:39 pm

Opinion – Lifelong Persistence of Toxoplasma Cysts: A Questionable Dogma?

Trends in Parasitology December 08, 2016

Solène Rougier, Jose G. Montoya, François Peyron

It is believed that infection by Toxoplasma gondii triggers a lifelong protective immunity due to the persistence of parasitic cysts which induce immunoprotection against reinfection.

A review of the scientific literature since the 1950s did not yield any definitive data regarding the duration of cysts in the host or the presence of lifelong protective immunity, which led us to question this dogma.

We put forward the hypothesis that sustained immunity to T. gondii requires repeated antigenic stimulations.

The decline of seroprevalence recently observed in many countries might contribute to explain the loss of immunity.

We address the potential consequences of this phenomenon, should it persist and worsen…



December 19, 2016 at 8:06 am

Listeria monocytogenes meningitis in an immunocompromised patient.

New Microbiol. 2015 Jan;38(1):113-8.

Barocci S1, Mancini A, Canovari B, Petrelli E, Sbriscia-Fioretti E, Licci A, D’Addesa S, Petrini G, Giacomini M, Renzi A, Migali A, Briscolini S.

Author information

1ASUR Marche AV2, O.U. Clinical Pathology, Senigallia (AN), Italy.


This report describes a case of meningitis caused by Listeria monocytogenes in a stem cell transplant recipient on immunosuppressive therapy for cutaneous chronic graft-versus host disease.

A 59-year-old woman had undergone allogeneic stem cell transplantation (from a matched unrelated donor) 13 months previously for chronic lymphocytic leukemia. She was on regular hematologic follow-up.

Though her previous malignancy has been in remission, she was immunosuppressed due to the pharmacological treatment.

We describe a meningitis caused by a typical food-borne pathogen, dangerous in patients with impaired cell-mediated immunity. Moreover the bacterium had a multidrug resistance, a rare characteristic in clinical listeriosis.

Rapid diagnosis and treatment are key factors in these cases. We chose ampicillin and rifampicin that allowed a complete resolution of the clinical manifestations.


December 18, 2016 at 12:22 pm

Listeriosis during Pregnancy: A Public Health Concern.

ISRN Obstet Gynecol. 2013 Sep 26;2013:851712. doi: 10.1155/2013/851712.

Mateus T1, Silva J, Maia RL, Teixeira P.

Author information

1Centro de Biotecnologia e Química Fina (CBQF) Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal ; Departamento de Medicina Veterinária (EUVG), Escola Universitária Vasco da Gama, Coimbra, Portugal.


Listeria was first described in 1926 by Murray, Webb, and Swann, who discovered it while investigating an epidemic infection among laboratory rabbits and guinea pigs. The role of Listeria monocytogenes as a foodborne pathogen was definitively recognized during the 1980s. This recognition was the consequence of a number of epidemic human outbreaks due to the consumption of contaminated foods, in Canada, in the USA and in Europe. Listeriosis is especially severe in immunocompromised individuals such as pregnant women. The disease has a low incidence of infection, although this is undeniably increasing, with a high fatality rate amongst those infected. In pregnant women listeriosis may cause abortion, fetal death, or neonatal morbidity in the form of septicemia and meningitis. Improved education concerning the disease, its transmission, and prevention measures for immunocompromised individuals and pregnant women has been identified as a pressing need.


April 24, 2016 at 2:17 pm

Infections by Listeria monocytogenes.

Rev Chilena Infectol. 2013 Aug;30(4):417-25.

[Article in Spanish]

Sedano R1, Fica A, Guiñez D, Braun S, Porte L, Dabanch J, Weitzel T, Soto A.

Author information

1Departamento de Medicina, Hospital Militar de Santiago, Santiago, Chile.



Listeria monocytogenes infections have been poorly characterized in Chile.


To evaluate clinical manifestations and risk factors associated to a fatal outcome in a series of patients.


retrospective analysis of cases from 1991 to 2012.


Twenty three cases were identified, including 2 diagnosed after prolonged hospitalization (8.7%) with an average age of 68.4 years (range 44-90). Known predisposing factors were age > 65 years (60.9%), diabetes mellitus (40.9%), and immunosuppression (27.3%). Most cases presented after 2003 (70%). No cases associated with neonates, pregnancy or HIV infections were recorded. Patients presented with central nervous system (CNS) infection (39%), including 8 cases of meningitis and one of rhomboencephalitis; bacteremia (43.5%), including one case with endocarditis; abscesses (8.7%); and other infections (spontaneous bacterial peritonitis and pneumonia; 8.7%). Risky food consumption was found in 80% of those asked about it. Predominant clinical manifestations were fever (90.9%), and confusion (63.6%). CNS infections were associated to headache (OR 21, p < 0.05), nausea and vomiting (OR 50, p < 0.01). Only 45.5% received initial appropriate empirical therapy and 36.4% a synergistic combination. Eight patients died (34.8%), this outcome was associated to bacteremia (OR 8.25; IC95 1.2-59 p < 0.05).


monocytogenes infections appear to be increasing in Chile, causing infections in different sites, attacking vulnerable patients, and have a high case-fatality ratio, especially among those with bacteremia.


April 24, 2016 at 2:15 pm

Antibiotic susceptibility of Listeria monocytogenes in Argentina

Enf Infecc y Microb Clínica Febrero 2016 V.34 N.02

Mónica Prieto a, Claudia Martínez a, Lorena Aguerre a, María Florencia Rocca a, Lucía Cipolla a, Raquel Callejo a

a Servicio Bacteriología Especial, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas (INEI) – Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) “Dr. Carlos G. Malbrán”, Ciudad Autónoma de Buenos Aires, Argentina


Listeria monocytogenes is the causative agent of listeriosis, a food-borne disease that mainly affects pregnant women, the elderly, and immunocompromised patients. The primary treatment of choice of listeriosis is the combination of ampicillin or penicillin G, with an aminoglycoside, classically gentamicin. The second-choice therapy for patients allergic to β-lactams is the combination of trimethoprim with a sulfonamide (such as co-trimoxazole). The aim of this study was to analyze the antimicrobial susceptibility profile of strains isolated from human infections and food during the last two decades in Argentina.


The minimal inhibitory concentration (MIC) of 8 antimicrobial agents was determined for a set of 250 strains of L. monocytogenes isolated in Argentina during the period 1992–2012. Food-borne and human isolates were included in this study. The antibiotics tested were ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, erythromycin, gentamicin, penicillin G, tetracycline and rifampicin. Breakpoints for penicillin G, ampicillin and trimethoprim-sulfamethoxazole were those given in the CLSI for L. monocytogenes. CLSI criteria for staphylococci were applied to the other antimicrobial agents tested. Strains were serotyped by PCR, and confirmed by an agglutination method.


Strains recovered from human listeriosis patients showed a prevalence of serotype 4b (71%), with the remaining 29% corresponding to serotype 1/2b. Serotypes among food isolates were distributed as 62% serotype 1/2b and 38% serotype 4b. All antimicrobial agents showed good activity.


The strains of L. monocytogenes isolated in Argentina over a period of 20 years remain susceptible to antimicrobial agents, and that susceptibility pattern has not changed during this period.



February 19, 2016 at 12:35 pm

Older Posts


July 2018
« Jun    

Posts by Month

Posts by Category