Posts filed under ‘Meta-Análisis’

Antibiotic prophylaxis in ureteroscopic lithotripsy: a systematic review and meta-analysis of comparative studies.

BJU Int. 2018 Jul;122(1):29-39.

Deng T1,2,3, Liu B4, Duan X1,2,3, Cai C1,2,3, Zhao Z1,2,3, Zhu W1,2,3, Fan J1,2,3, Wu W1,2,3, Zeng G1,2,3.

Author information

1 Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

2 Guangzhou Institute of Urology, Guangzhou, China.

3 Guangdong Key Laboratory of Urology, Guangzhou, China.

4 The First Affiliated Hospital of Jinan University, Guangzhou, China.



To explore the efficacy of antibiotic prophylaxis and the different strategies used to prevent infection in ureteroscopic lithotripsy (URL) by conducting a systematic review and meta-analysis.


A systematic literature search using Pubmed, Embase, Medline, the Cochrane Library, and the Chinese CBM, CNKI and VIP databases was performed to find comparative studies on the efficacy of different antibiotic prophylaxis strategies in URL for preventing postoperative infections. The last search was conducted on 25 June 2017. Summarized unadjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the efficacy of different antibiotic prophylaxis strategies.


A total of 11 studies in 4 591 patients were included in this systematic review and meta-analysis. No significant difference was found in the risk of postoperative febrile urinary tract infections (fUTIs) between groups with and without antibiotic prophylaxis (OR: 0.82, 95% CI 0.40-1.67; P = 0.59). Patients receiving a single dose of preoperative antibiotics had a significantly lower risk of pyuria (OR: 0.42, 95% CI 0.25-0.69; P = 0.0007) and bacteriuria (OR: 0.25, 95% CI 0.11-0.58; P = 0.001) than those who did not. Intravenous antibiotic prophylaxis was not superior to single-dose oral antibiotic prophylaxis in reducing fUTI (OR: 1.00, 95% CI 0.26-3.88; P = 1.00).


We concluded that preoperative antibiotic prophylaxis did not lower the risk of postoperative fUTI, but a single dose could reduce the incidence of pyuria or bacteriuria. A single oral dose of preventive antibiotics is preferred because of its cost-effectiveness. The efficacy of different types of antibiotics and other strategies could not be assessed in our meta-analysis. Randomized controlled trials with a larger sample size and more rigorous study design are needed to validate these conclusions.




July 27, 2018 at 12:59 pm

Global etiology of bacterial meningitis: A systematic review and meta-analysis.

PLoS One. 2018 Jun 11;13(6):e0198772.

Oordt-Speets AM1, Bolijn R1, van Hoorn RC1, Bhavsar A2, Kyaw MH3.


Bacterial meningitis is a global public health concern, with several responsible etiologic agents that vary by age group and geographical area. The aim of this systematic review and meta-analysis was to assess the etiology of bacterial meningitis in different age groups across global regions.

PubMed and EMBASE were systematically searched for English language studies on bacterial meningitis, limited to articles published in the last five years. The methodological quality of the studies was assessed using a customized scoring system.

Meta-analyses were conducted to determine the frequency (percentages) of seven bacterial types known to cause meningitis: Escherichia coli, Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae, group B Streptococcus agalactiae, Staphylococcus aureus, and Listeria monocytogenes, with results being stratified by six geographical regions as determined by the World Health Organization, and seven age groups.

Of the 3227 studies retrieved, 56 were eligible for the final analysis. In all age groups, S. pneumoniae and N. meningitidis were the predominant pathogens in all regions, accounting for 25.1-41.2% and 9.1-36.2% of bacterial meningitis cases, respectively. S. pneumoniae infection was the most common cause of bacterial meningitis in the ‘all children’ group, ranging from 22.5% (Europe) to 41.1% (Africa), and in all adults ranging from 9.6% (Western Pacific) to 75.2% (Africa).

E. coli and S. pneumoniae were the most common pathogens that caused bacterial meningitis in neonates in Africa (17.7% and 20.4%, respectively). N. meningitidis was the most common in children aged ±1-5 years in Europe (47.0%).

Due to paucity of data, meta-analyses could not be performed in all age groups for all regions. A clear difference in the weighted frequency of bacterial meningitis cases caused by the different etiological agents was observed between age groups and between geographic regions.

These findings may facilitate bacterial meningitis prevention and treatment strategies.


July 19, 2018 at 3:39 pm

Association Between CMV Reactivation and Clinical Outcomes in Immunocompetent Critically Ill Patients – Systematic Review and Meta-Analysis July 2018


The aim of our systematic review was to investigate the association between cytomegalovirus (CMV) reactivation and outcomes in immunocompetent critically ill patients.


We searched electronic databases and gray literature for original studies and abstracts published between 1990 and October 2016. The review was limited to studies including critically ill immunocompetent patients. Cytomegalovirus reactivation was defined as positive polymerase chain reaction, pp65 antigenemia, or viral culture from blood or bronchoalveolar lavage. Selected patient-centered outcomes included mortality, duration of mechanical ventilation, need for renal replacement therapy (RRT), and nosocomial infections. Health resource utilization outcomes included intensive care unit and hospital lengths of stay.


Twenty-two studies were included. In our primary analysis, CMV reactivation was associated with increased ICU mortality (odds ratio [OR], 2.55; 95% confidence interval [CI], 1.87–3.47), overall mortality (OR, 2.02; 95% CI, 1.60–2.56), duration of mechanical ventilation (mean difference 6.60 days; 95% CI, 3.09–10.12), nosocomial infections (OR, 3.20; 95% CI, 2.05–4.98), need for RRT (OR, 2.37; 95% CI, 1.31–4.31), and ICU length of stay (mean difference 8.18 days; 95% CI, 6.14–10.22). In addition, numerous sensitivity analyses were performed.


In this meta-analysis, CMV reactivation was associated with worse clinical outcomes and greater health resource utilization in critically ill patients. However, it remains unclear whether CMV reactivation plays a causal role or if it is a surrogate for more severe illness.


July 15, 2018 at 3:48 pm

Selective digestive and oropharyngeal decontamination in medical and surgical ICU patients: individual patient data meta-analysis

Clinical Microbiology abd Infection May 2018 V.24 N.5 P.505-513

N.L. Plantinga, A.M.G.A. de Smet, E.A.N. Oostdijk, E. de Jonge, C. Camus, W.A. Krueger, D. Bergmans, J.B. Reitsma, M.J.M. Bonten


Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) improved intensive care unit (ICU), hospital and 28-day survival in ICUs with low levels of antibiotic resistance. Yet it is unclear whether the effect differs between medical and surgical ICU patients.


In an individual patient data meta-analysis, we systematically searched PubMed and included all randomized controlled studies published since 2000. We performed a two-stage meta-analysis with separate logistic regression models per study and per outcome (hospital survival and ICU survival) and subsequent pooling of main and interaction effects.


Six studies, all performed in countries with low levels of antibiotic resistance, yielded 16 528 hospital admissions and 17 884 ICU admissions for complete case analysis. Compared to standard care or placebo, the pooled adjusted odds ratios for hospital mortality was 0.82 (95% confidence interval (CI) 0.72–0.93) for SDD and 0.84 (95% CI 0.73–0.97) for SOD. Compared to SOD, the adjusted odds ratio for hospital mortality was 0.90 (95% CI 0.82–0.97) for SDD. The effects on hospital mortality were not modified by type of ICU admission (p values for interaction terms were 0.66 for SDD and control, 0.87 for SOD and control and 0.47 for SDD and SOD). Similar results were found for ICU mortality.


In ICUs with low levels of antibiotic resistance, the effectiveness of SDD and SOD was not modified by type of ICU admission. SDD and SOD improved hospital and ICU survival compared to standard care in both patient populations, with SDD being more effective than SOD.




June 12, 2018 at 8:07 am

Inappropriate Management of Asymptomatic Patients With Positive Urine Cultures: A Systematic Review and Meta-analysis

Open Forum Infectious Diseases Fall 2017 V.4 N.4

Myrto Eleni Flokas; Nikolaos Andreatos; Michail Alevizakos; Alireza Kalbasi; Pelin Onur …


La mala gestión de pacientes asintomáticos con cultivos de orina positivos (denominada bacteriuria asintomática [ASB] en la literatura) promueve la resistencia a los antimicrobianos y da como resultado eventos adversos innecesarios relacionados con los antimicrobianos y mayores costos de atención médica.


Llevamos a cabo una revisión sistemática y un metanálisis de estudios que informaron sobre la tasa de tratamiento ASB inapropiado publicado entre 2004 y agosto 2016. La idoneidad de la administración de antimicrobianos se basó en las guias publicadas por la Sociedad de Enfermedades Infecciosas de América (IDSA).


Se identificaron 2142 artículos no duplicados, y entre ellos 30 cumplieron nuestros criterios de inclusión. La prevalencia combinada del tratamiento antimicrobiano entre 4129 casos que no requirieron tratamiento fue del 45% (IC 95%, 39-50). Aislamiento de BGN (odds ratio [OR], 3,58; IC del 95%, 2,12-6,06), piuria (OR, 2,83; IC del 95%, 1,9-4,22), positividad del nitrito (OR, 3,83; IC del 95%; 2.24-6.54), y el sexo femenino (OR, 2.11, IC 95%, 1.46-3.06) aumentaron las probabilidades de recibir tratamiento. Las tasas de tratamiento fueron más altas en estudios con valores de corte de ≥ 100 000 ufc/ml en comparación con < 10 000 ufc/ml para el crecimiento bacteriano (P, 0,011). La implementación de intervenciones educativas y organizacionales diseñadas para eliminar el sobretratamiento de ASB resultó en una reducción media del riesgo absoluto del 33% (rangeARR, 16-36%, medianaRRR, 53%; rangeRRR, 25-80%).


La mala gestión de ASB sigue siendo extremadamente frecuente. El sexo femenino y la sobreinterpretación de ciertos datos de laboratorio (nitritos positivos, piuria, aislamiento de bacterias gramnegativas y cultivos con mayor recuento microbiano) están asociados con el sobretratamiento. Incluso las intervenciones simples de mayordomía pueden ser particularmente efectivas, y los programas de administración de antimicrobianos deben enfocarse en el desafío de diferenciar la infección verdadera del tracto urinario de ASB.




April 9, 2018 at 1:13 pm

C-reactive protein level predicts mortality in COPD – systematic review and meta-analysis

European Respiratory Review 31 March 2017 V.26 N.143   

El nivel de PCR predice la mortalidad en la EPOC – revisión sistemática y metanálisis

Giovanni Leuzzi, Carlotta Galeone, Francesca Taverna, Paola Suatoni, Daniele Morelli, Ugo Pastorino

El papel pronóstico de la proteína C-reactiva (PCR) en la EPOC es controvertido.

Para aclarar este problema, se realizó una revisión sistemática y un metanálisis para evaluar el efecto predictivo del nivel de PCR inicial en pacientes con EPOC. 15 artículos elegibles que se centran en la mortalidad tardía en la EPOC se incluyeron en nuestro estudio.

Realizamos un metanálisis de efectos aleatorios y evaluamos la heterogeneidad y el sesgo de publicación. Se combinaron las estimaciones de la razón de riesgo (HR) y sus intervalos de confianza del 95% sobre la mortalidad para la comparación entre la categoría más alta de PCR del estudio específico frente a la categoría más baja.

En el análisis general, los niveles elevados de PCR basales se asociaron significativamente con una mayor mortalidad (HR 1,53; IC del 95%: 1,32-1,77; I2 = 68,7%; p <0,001). Se observaron resultados similares en todos los subgrupos. Sin embargo, se informó un mayor riesgo de mortalidad en los estudios que utilizaron un valor de corte de 3 mg · L-1 (HR 1.61, IC 95% 1.12-2.30) y en aquellos que reclutaron una población asiática (HR 3.51, IC 95% 1.69-7.31 )

Nuestro análisis indica que el nivel de PCR alto basal se asocia significativamente con una mayor mortalidad tardía en pacientes con EPOC. Se necesitan más estudios controlados prospectivos para confirmar estos datos.




March 25, 2018 at 4:35 pm

Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: a systematic review and meta-analysis.

Crit Care Med. 2010 Sep;38(9):1802-8.

Kalil AC1, Murthy MH, Hermsen ED, Neto FK, Sun J, Rupp ME.

Author information

1 University of Nebraska Medical Center, Omaha, NE, USA.



Compared with glycopeptides, linezolid achieves higher lung epithelial lining fluid concentrations, which may correlate with improved efficacy in the treatment of nosocomial pneumonia. However, clinical superiority has not been demonstrated.


To test the hypothesis that linezolid may be superior to glycopeptides.


Prospective randomized trials that tested linezolid vs. vancomycin or teicoplanin for treatment of nosocomial pneumonia were included. Heterogeneity was analyzed by I(2) and Q statistics. Meta-analysis relative risks were based on fixed and random-effects models. Outcomes evaluated consisted of clinical cure, microbiological eradication, and side effects.


Nine linezolid trials (vancomycin [7]; teicoplanin [2]) were included (n = 2329). The linezolid vs. glycopeptide analysis shows clinical cure relative risk of 1.01 (95% confidence interval, 0.93-1.10; p = .83; I(2) = 0%) and microbiological eradication relative risk of 1.10 (95% confidence interval, 0.98 -1.22; p = .10; I(2) = 0%). Methicillin-resistant Staphylococcus aureus subgroup analysis yielded a microbiological eradication relative risk of 1.10 (95% confidence interval, 0.87-1.38; p = .44; I(2) = 16%). If linezolid is compared with vancomycin only, then clinical cure relative risk is 1.00 (95% confidence interval, 0.90-1.12), microbiological eradication and methicillin-resistant Staphylococcus aureus relative risks are 1.07 (95% confidence interval, 0.90-1.26; p = .45) and 1.05 (95% confidence interval, 0.82-1.33; p = .71). The risks of thrombocytopenia (relative risk, 1.93; 95% confidence interval, 1.30-2.87; p = .001) and gastrointestinal events (relative risk, 2.02; 95% confidence interval, 1.10-3.70; p = .02) are higher with linezolid, but no differences are seen for renal dysfunction (relative risk, 0.89; 95% confidence interval, 0.56-1.43; p = .64) or all-cause mortality (relative risk, 0.95; 95% confidence interval, 0.76-1.18; p = .63).


Our study does not demonstrate clinical superiority of linezolid vs. glycopeptides for the treatment of nosocomial pneumonia despite a statistical power of 95%. Linezolid shows a significant two-fold increase in the risk of thrombocytopenia and gastrointestinal events. Vancomycin and teicoplanin are not associated with more renal dysfunction than linezolid.



March 24, 2018 at 10:56 am

Older Posts Newer Posts


February 2020
« Jan    

Posts by Month

Posts by Category